An Outbreak of Coxsackievirus A6 Infection in Adults of a Collective Unit, China, 2019.

IF 2.6
Yumeng Gao, Guangyuan Ma, Yong Xiao, Qun Cai, Yujun Chen, Ping Shi, Kewei Wang, Yuan Shen, Chao Shi
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引用次数: 1

Abstract

Outbreaks/epidemics caused by coxsackievirus A6 (CVA6) have been reported continuously since 2008. However, outbreaks of ocular conjunctival hemorrhage caused by CVA6 in adults in a collective unit have not been reported. Methods. The epidemiological investigations were carried out according to the monitoring program, and the clinical data were collected from the treated hospitals. The nasopharyngeal swab specimens were collected to extract the total nucleic acid (DNA/RNA). The pathogen was determined using nucleic acid detection kits for 22 respiratory pathogens. The VP1 gene of this pathogen was amplified and sequenced. Sequence alignment and analysis were performed using BioEdit 7.0. The gene phylogenetic tree was constructed with MEGA4.0. Results. The factory emerged patients in succession from February 14 and reached the peak on the 18th. A total of 19 workers had symptoms in this factory up to March 31, 2019, giving an attack rate of 8.26%. The main symptoms were rash, ocular conjunctival hemorrhage, fever, and sore throat. The laboratory results showed that coxsackievirus A6 was the main pathogen causing this outbreak. The risk of taking a bath in the bathroom was 7.37 times higher than that of not taking a bath (95% confidence interval (CI): 1.67-32.79). Conclusion. This manuscript further enriched the infection-related information of CVA6, which was helpful to better identify and deal with the epidemic in the future.

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2019年中国某集体单位成人柯萨奇病毒A6感染暴发
柯萨奇病毒A6 (CVA6)引起的暴发/流行自2008年以来不断有报告。然而,由CVA6引起的成人集体结膜出血的暴发尚未见报道。方法。根据监测方案开展流行病学调查,收集收治医院的临床资料。采集鼻咽拭子标本,提取总核酸(DNA/RNA)。采用核酸检测试剂盒对22种呼吸道病原菌进行检测。对该病原菌的VP1基因进行扩增和测序。使用BioEdit 7.0进行序列比对和分析。利用MEGA4.0构建基因系统发育树。结果。工厂从2月14日开始陆续出现患者,18日达到高峰。截至2019年3月31日,该工厂共有19名工人出现症状,发病率为8.26%。主要症状为皮疹、眼结膜出血、发热、咽喉痛。实验室结果表明,柯萨奇病毒A6是这次暴发的主要病原体。在浴室洗澡的风险比不洗澡的风险高7.37倍(95%置信区间(CI): 1.67-32.79)。结论。本文进一步丰富了CVA6的感染相关信息,有助于今后更好地识别和应对疫情。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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