Sweat gland morphology and physiology in diabetes, neuropathy, and nephropathy: a review.

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2024-08-01 Epub Date: 2022-09-05 DOI:10.1080/13813455.2022.2114499

Sudha Singaram, Kalpana Ramakrishnan, Jayashree Selvam, Mallika Senthil, Vigneswaran Narayanamurthy

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引用次数: 0

Abstract

Context: Sweat glands (SGs) play a vital role in thermal regulation. The function and structure are altered during the different pathological conditions.Objective: These alterations are studied through three techniques: biopsy, sweat analytes and electrical activity of SG.Methods: The morphological study of SG through biopsy and various techniques involved in quantifying sweat analytes is focussed on here. Electrical activities of SG in diabetes, neuropathy and nephropathy cases are also discussed, highlighting their limitations and future scope.Results and Conclusion: The result of this review identified three areas of the knowledge gap. The first is wearable sensors to correlate pathological conditions. Secondly, there is no device to look for its structure and quantify its associated function. Finally, therapeutic applications of SG are explored, especially for renal failure. With these aspects, this paper provides information collection and correlates SG with pathologies related to diabetes. Hence this could help researchers develop suitable technologies for the gaps identified.

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糖尿病、神经病变和肾病的汗腺形态和生理：综述。

背景：汗腺在热调节中发挥着重要作用。在不同的病理情况下，汗腺的功能和结构都会发生改变：方法：通过活检、汗液分析物和 SG 的电活动这三种技术来研究这些变化：方法：通过活检对 SG 进行形态学研究，并采用各种技术对汗液分析物进行定量分析。还讨论了糖尿病、神经病变和肾病病例中的 SG 电活动，强调了其局限性和未来的发展空间：综述结果发现了三个知识空白领域。首先是与病理条件相关的可穿戴传感器。其次，目前还没有一种设备可以检测其结构并量化其相关功能。最后是探索 SG 的治疗应用，尤其是肾功能衰竭。基于这些方面，本文提供了信息收集，并将 SG 与糖尿病相关病症联系起来。因此，这将有助于研究人员针对发现的差距开发合适的技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.