The Profiles of Laryngopharyngeal Reflux in Patients With Different Vocal Fold Lesions.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-09-02 DOI:10.1016/j.jvoice.2022.08.002

Jinhong Zhang, Xiaoyu Wang, Jiasen Wang, Jing Zhao, Chun Zhang, Zhi Liu, Jinrang Li

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引用次数: 0

Abstract

Objectives: To investigate the profiles of laryngopharyngeal reflux (LPR) and the relationship between hypopharyngeal-proximal reflux episodes (HREs) and the positive rate of salivary pepsin testing in patients with vocal fold lesions (VFLs).

Methods: The enrolled patients were divided into vocal fold cancer group (VFCG), vocal fold leukoplakia group (VFLG), benign vocal fold lesion group (BVFLG) and control group (CG). Patients benefited from multichannel intraluminal impedance-pH monitoring (MII-pH) and multi-time point salivary pepsin testing (MTPSPT). The LPR profiles of patients with VFLs were studied by analyzing the MII-pH findings. The relationship between HREs and positive rate of MTPSPT was investigated through the nonparametric test.

Results: 177 patients were included. According to 24 h MII-pH, the occurrence of HREs tended to increase after meals. 55.75%, 63.98%, 66.82% and 55.77% of the HREs in the VFCG, VFLG, BVFLG and CG occurred within 3 h after meals, respectively. The overall positive rate of MTPSPT was higher in the VFCG than the remaining groups. In the VFCG, there was a significant correlation between overall positive results of MTPSPT and HREs occurring within 3 h after meals.

Conclusion: In the Chinese population, the occurrence of HREs tend to more frequently after meals in patients with VFLs, and most HREs occur within 3 h after meals. By analyzing the 24h MII-pH findings, we can develop a more individualized anti-reflux therapeutic strategy for LPR patients.

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不同声带病变患者的喉咽反流特征

研究目的研究声带病变（VFLs）患者的喉咽反流（LPR）情况以及下咽-近端反流发作（HREs）与唾液胃蛋白酶检测阳性率之间的关系：入组患者分为声带癌组（VFCG）、声带白斑组（VFLG）、声带良性病变组（BVFLG）和对照组（CG）。患者接受了多通道腔内阻抗-声压监测（MII-pH）和多时点唾液胃蛋白酶检测（MTPSPT）。通过分析 MII-pH 结果，研究了 VFL 患者的 LPR 特征。通过非参数检验研究了 HRE 与 MTPSPT 阳性率之间的关系：共纳入 177 名患者。根据 24 小时的 MII-pH，餐后 HRE 的发生率呈上升趋势。在 VFCG、VFLG、BVFLG 和 CG 中，分别有 55.75%、63.98%、66.82% 和 55.77% 的 HRE 发生在餐后 3 小时内。VFCG 的 MTPSPT 整体阳性率高于其他组别。在 VFCG 中，MTPSPT 的总体阳性结果与餐后 3 小时内发生的 HRE 之间存在显著相关性：结论：在中国人群中，VFL 患者餐后发生 HRE 的频率更高，且大多数 HRE 发生在餐后 3 小时内。通过分析 24 小时 MII-pH 结果，我们可以为 LPR 患者制定更加个性化的抗反流治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.