Cognitive Functioning of Unaffected First-degree Relatives of Individuals With Late-onset Alzheimer's Disease: A Systematic Literature Review and Meta-analysis.

IF 5.4 2区心理学 Q1 NEUROSCIENCES

Neuropsychology Review Pub Date : 2023-12-01 Epub Date: 2022-09-03 DOI:10.1007/s11065-022-09555-2

Ari Alex Ramos, Noelia Galiano-Castillo, Liana Machado

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引用次数: 3

Abstract

First-degree relatives of individuals with late-onset Alzheimer's disease (LOAD) are at increased risk for developing dementia, yet the associations between family history of LOAD and cognitive dysfunction remain unclear. In this quantitative review, we provide the first meta-analysis on the cognitive profile of unaffected first-degree blood relatives of LOAD-affected individuals compared to controls without a family history of LOAD. A systematic literature search was conducted in PsycINFO, PubMed /MEDLINE, and Scopus. We fitted a three-level structural equation modeling meta-analysis to control for non-independent effect sizes. Heterogeneity and risk of publication bias were also investigated. Thirty-four studies enabled us to estimate 218 effect sizes across several cognitive domains. Overall, first-degree relatives (n = 4,086, mean age = 57.40, SD = 4.71) showed significantly inferior cognitive performance (Hedges' g = -0.16; 95% CI, -0.25 to -0.08; p < .001) compared to controls (n = 2,388, mean age = 58.43, SD = 5.69). Specifically, controls outperformed first-degree relatives in language, visuospatial and verbal long-term memory, executive functions, verbal short-term memory, and verbal IQ. Among the first-degree relatives, APOE ɛ4 carriership was associated with more significant dysfunction in cognition (g = -0.24; 95% CI, -0.38 to -0.11; p < .001) compared to non-carriers (g = -0.14; 95% CI, -0.28 to -0.01; p = .04). Cognitive test type was significantly associated with between-group differences, accounting for 65% (R²₃ = .6499) of the effect size heterogeneity in the fitted regression model. No evidence of publication bias was found. The current findings provide support for mild but robust cognitive dysfunction in first-degree relatives of LOAD-affected individuals that appears to be moderated by cognitive domain, cognitive test type, and APOE ɛ4.

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晚期阿尔茨海默氏症患者未受影响的一级亲属的认知功能：系统文献综述与元分析》。

晚发性阿尔茨海默病（LOAD）患者的一级亲属患痴呆症的风险增加，但LOAD家族史与认知功能障碍之间的关系仍不清楚。在这篇定量综述中，我们首次对 LOAD 患者未受影响的一级血亲与无 LOAD 家族史的对照组的认知概况进行了荟萃分析。我们在 PsycINFO、PubMed /MEDLINE 和 Scopus 中进行了系统的文献检索。我们进行了三级结构方程建模荟萃分析，以控制非独立效应大小。我们还对异质性和发表偏差风险进行了调查。通过 34 项研究，我们估算出了多个认知领域的 218 个效应大小。总体而言，在拟合回归模型中，一级亲属（n = 4,086 人，平均年龄 = 57.40 岁，SD = 4.71）的认知表现明显较差（Hedges' g = -0.16; 95% CI, -0.25 to -0.08; p 23 = .6499）。没有发现发表偏倚的证据。目前的研究结果表明，受 LOAD 影响的个体的一级亲属存在轻微但强大的认知功能障碍，这种障碍似乎受认知领域、认知测试类型和 APOE ɛ4 的调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychology Review 医学-神经科学

CiteScore

11.00

自引率

1.70%

发文量

期刊介绍： Neuropsychology Review is a quarterly, refereed publication devoted to integrative review papers on substantive content areas in neuropsychology, with particular focus on populations with endogenous or acquired conditions affecting brain and function and on translational research providing a mechanistic understanding of clinical problems. Publication of new data is not the purview of the journal. Articles are written by international specialists in the field, discussing such complex issues as distinctive functional features of central nervous system disease and injury; challenges in early diagnosis; the impact of genes and environment on function; risk factors for functional impairment; treatment efficacy of neuropsychological rehabilitation; the role of neuroimaging, neuroelectrophysiology, and other neurometric modalities in explicating function; clinical trial design; neuropsychological function and its substrates characteristic of normal development and aging; and neuropsychological dysfunction and its substrates in neurological, psychiatric, and medical conditions. The journal''s broad perspective is supported by an outstanding, multidisciplinary editorial review board guided by the aim to provide students and professionals, clinicians and researchers with scholarly articles that critically and objectively summarize and synthesize the strengths and weaknesses in the literature and propose novel hypotheses, methods of analysis, and links to other fields.