Changes in vestibular and cochlear function following platinum-based chemotherapy: A preliminary report.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2025-06-01 Epub Date: 2022-09-02 DOI:10.1177/01455613221115042

Katerina Ehlert, Barbara Heinze, Marien A Graham, De Wet Swanepoel

{"title":"Changes in vestibular and cochlear function following platinum-based chemotherapy: A preliminary report.","authors":"Katerina Ehlert, Barbara Heinze, Marien A Graham, De Wet Swanepoel","doi":"10.1177/01455613221115042","DOIUrl":null,"url":null,"abstract":"ObjectivesThis study investigated the changes in vestibular and cochlear function in patients receiving platinum-based chemotherapy.MethodsA longitudinal study of 32 participants (10-70 years) receiving chemotherapy participated in the study. Baseline and exit vestibular and hearing assessments that included video head impulse (VHIT) testing, cervical and ocular vestibular evoked myogenic potentials (VEMP), dynamic visual acuity (DVA) and pure-tone audiometry were performed at the patient's treatment venue.ResultsHalf (50%) of the participants showed cochleotoxicity from baseline to exit testing, with left ears significantly more affected than right ears. There was no consistent relationship between hearing loss and vestibular dysfunction. DVA yielded normal results at baseline and exit testing in all participants. VEMP responses were absent in 28.1% of participants at baseline, reflecting the challenges of using VEMP for monitoring. VEMP and VHIT results showed a statistically significant (p < 0.05) decline in results from baseline to exit testing; however, participants did not report symptoms related to vestibular dysfunction. VHIT also showed left ears significantly (p < 0.05) more affected than right ears.ConclusionVHIT proved to be a valuable measure of changes in vestibular function secondary to ototoxicity. Future investigations should determine vestibulotoxicity criteria and optimal protocols for vestibulotoxicity monitoring at the patient's treatment venue.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"NP337-NP348"},"PeriodicalIF":16.4000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1177/01455613221115042","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/9/2 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

ObjectivesThis study investigated the changes in vestibular and cochlear function in patients receiving platinum-based chemotherapy.MethodsA longitudinal study of 32 participants (10-70 years) receiving chemotherapy participated in the study. Baseline and exit vestibular and hearing assessments that included video head impulse (VHIT) testing, cervical and ocular vestibular evoked myogenic potentials (VEMP), dynamic visual acuity (DVA) and pure-tone audiometry were performed at the patient's treatment venue.ResultsHalf (50%) of the participants showed cochleotoxicity from baseline to exit testing, with left ears significantly more affected than right ears. There was no consistent relationship between hearing loss and vestibular dysfunction. DVA yielded normal results at baseline and exit testing in all participants. VEMP responses were absent in 28.1% of participants at baseline, reflecting the challenges of using VEMP for monitoring. VEMP and VHIT results showed a statistically significant (p < 0.05) decline in results from baseline to exit testing; however, participants did not report symptoms related to vestibular dysfunction. VHIT also showed left ears significantly (p < 0.05) more affected than right ears.ConclusionVHIT proved to be a valuable measure of changes in vestibular function secondary to ototoxicity. Future investigations should determine vestibulotoxicity criteria and optimal protocols for vestibulotoxicity monitoring at the patient's treatment venue.

查看原文本刊更多论文

铂类化疗后前庭和耳蜗功能的变化：初步报告

研究目的本研究调查了接受铂类化疗患者的前庭和耳蜗功能变化：32名接受化疗的患者（10-70岁）参加了这项纵向研究。在患者的治疗地点进行了基线和出口前庭和听力评估，包括视频头脉冲（VHIT）测试、颈部和眼部前庭诱发肌源性电位（VEMP）、动态视力（DVA）和纯音测听：一半（50%）的参与者从基线测试到退出测试都出现了耳蜗毒性，左耳受影响程度明显高于右耳。听力损失与前庭功能障碍之间没有一致的关系。所有参与者在基线和退出测试时的 DVA 结果均正常。28.1%的参与者在基线测试时没有 VEMP 反应，这反映了使用 VEMP 进行监测所面临的挑战。VEMP 和 VHIT 结果显示，从基线测试到退出测试，其结果均出现了统计学意义上的显著下降（p < 0.05）；然而，参与者并未报告与前庭功能障碍有关的症状。VHIT 还显示左耳受影响程度明显高于右耳（P < 0.05）：结论：VHIT 被证明是衡量耳毒性继发前庭功能变化的重要指标。未来的研究应确定前庭毒性标准，以及在患者治疗地点进行前庭毒性监测的最佳方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.