Feasibility and Safety of ERCP in the Treatment of Biliary Strictures after Liver Transplantation: With a Report of 37 Cases.

IF 2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterology Research and Practice Pub Date : 2022-08-23 eCollection Date: 2022-01-01 DOI:10.1155/2022/4498443

Fanfan Tang, Jingtao Song, Tanxing Cai, Zhao Lei, Feizhou Huang, Yina Hu, Gang Deng

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引用次数: 0

Abstract

Background: Liver transplantation (LT) is an effective treatment option for patients with end-stage liver disease; biliary complications are important cause of death in posttransplant patients. Endoscopic retrograde cholangiopancreatography (ERCP) has an irreplaceable role in the diagnosis and treatment of patients with biliary tract disease.

Methods: The clinical data of patients with biliary strictures (BS) after LT treated with ERCP admitted to the Third Xiangya Hospital of Central South University from September 2016 to October 2021 were reviewed; the changes in temperature, bilirubin, and albumin before and after treatment and postoperative complications were analyzed.

Results: A total of 41 patients were included in the study, and biliary stents were successfully placed in 37 cases (90.2%), while 4 cases (9.8%) were unsuccessful due to complete BS. Patients with ERCP guided biliary stenting had a significant improvement in bilirubin index compared to the preoperative period (P < 0.05). 27 patients (73.0%) had complete relief of symptoms after 1 ERCP-guided treatment, and 10 patients (27.0%) developed BS again at different times after the first ERCP treatment, among which 8 patients developed BS again within 1 year after the first treatment and 2 patients developed BS again after 1 year after the first treatment. The incidence of endoscopy-related adverse events was 35.14%, with no serious adverse events.

Conclusion: ERCP-guided biliary stenting was an effective and safety treatment for BS after LT.

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ERCP治疗肝移植后胆道狭窄的可行性及安全性:附37例报告

背景:肝移植(LT)是终末期肝病患者的有效治疗选择;胆道并发症是肾移植术后患者死亡的重要原因。内镜逆行胆管造影(ERCP)在胆道疾病患者的诊断和治疗中具有不可替代的作用。方法:回顾性分析2016年9月至2021年10月中南大学湘雅第三医院经ERCP治疗后胆道狭窄(BS)患者的临床资料;分析治疗前后患者体温、胆红素、白蛋白的变化及术后并发症。结果:共纳入41例患者，37例(90.2%)成功放置胆道支架，4例(9.8%)因完全性BS而失败。ERCP引导下胆道支架置入术患者胆红素指数较术前有显著改善(P < 0.05)。27例患者(73.0%)经1次ERCP指导治疗后症状完全缓解，10例患者(27.0%)在第一次ERCP治疗后不同时间再次出现BS，其中8例患者在第一次治疗后1年内再次出现BS, 2例患者在第一次治疗后1年内再次出现BS。内镜相关不良事件发生率为35.14%，无严重不良事件发生。结论:ercp引导下胆道支架置入术是治疗肝移植后BS的有效且安全的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.