Dopamine D₂ and Adenosine A_2A Receptors Interaction on Ca²⁺ Current Modulation in a Rodent Model of Parkinsonism.

IF 3.9 4区医学 Q2 NEUROSCIENCES

ASN NEURO Pub Date : 2022-01-01 DOI:10.1177/17590914221102075

Ernesto Alberto Rendón-Ochoa, Montserrat Padilla-Orozco, Vladimir Melesio Calderon, Victor Hugo Avilés-Rosas, Omar Hernández-González, Teresa Hernández-Flores, María Belén Perez-Ramirez, Marcela Palomero-Rivero, Elvira Galarraga, José Bargas

引用次数: 0

Abstract

Summary statement: A_2A receptor required previous D₂ receptor activation to modulate Ca²⁺ currents. Istradefylline decreases pramipexole modulation on Ca²⁺ currents. Istradefylline reduces A_2A + neurons activity in striatial microcircuit, but pramipexole failed to further reduce neuronal activity.

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多巴胺D2和腺苷A2A受体在帕金森病啮齿动物模型中Ca2+电流调节中的相互作用。

概述:A2A受体需要先前D2受体激活来调节Ca2+电流。伊斯特defylline降低普拉克索对Ca2+电流的调制。isstradefylline降低纹状微回路A2A +神经元活性，而普拉克索不能进一步降低神经元活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ASN NEURO NEUROSCIENCES-

CiteScore

7.70

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： ASN NEURO is an open access, peer-reviewed journal uniquely positioned to provide investigators with the most recent advances across the breadth of the cellular and molecular neurosciences. The official journal of the American Society for Neurochemistry, ASN NEURO is dedicated to the promotion, support, and facilitation of communication among cellular and molecular neuroscientists of all specializations.

Dopamine D2 and Adenosine A2A Receptors Interaction on Ca2+ Current Modulation in a Rodent Model of Parkinsonism.

Abstract

Dopamine D₂ and Adenosine A_2A Receptors Interaction on Ca²⁺ Current Modulation in a Rodent Model of Parkinsonism.