Retinal Vascular Caliber in Coronary Heart Disease and Its Risk Factors.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2023-01-01 Epub Date: 2022-08-31 DOI:10.1159/000526753

Changsen Liang, Chen Gu, Ning Wang

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引用次数: 0

Abstract

Background: Many clinical and experimental articles have suggested that the retinal vascular diameter can be used as a predictor of coronary heart disease (CHD). However, the results and reliability of the prediction are still controversial.

Objective: A meta-analysis of observational study was conducted to clarify the relationships of retinal vessel caliber with CHD and CHD risk factors.

Method: PubMed and Embase were searched for all observational studies on the relationship of retinal vessel caliber with CHD and CHD risk factors from 2001 to 2021. The meta-analysis has been registered in PROSPERO (registration number is CRD42021267154).

Result: A total of 14 articles were selected for the inclusion in this meta-analysis. In the primary outcome, smaller retinal arteriolar caliber was related to CHD, and the results achieved statistical significance (MD: -5.55, 95% CI: -8.07 to -3.02, p < 0.0001), while there was no significant difference in vein caliber between CHD and healthy people (MD: 1.10, 95% CI: -3.55 to 5.76, p = 0.64 > 0.05). Smaller retinal arteriolar caliber was related to increasing age, male sex, bigger BMI, and hypertension. Bigger retinal arteriolar caliber was related to current smoking. Smaller retinal venule caliber was related to increasing age and hypertension. Bigger retinal venule caliber was related to current smoking, bigger BMI, and diabetes.

Conclusion: Smaller retinal arteriolar caliber was related to CHD, while there was no significant difference in venule caliber between CHD and healthy people. Retinal vascular caliber also independently related to CHD risk factors (e.g., age, gender, smoke, BMI, hypertension, and diabetes).

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冠心病及其风险因素中的视网膜血管口径

背景：许多临床和实验文章都认为视网膜血管直径可作为冠心病（CHD）的预测指标。然而，预测的结果和可靠性仍存在争议：对观察性研究进行荟萃分析，以明确视网膜血管直径与冠心病及冠心病危险因素的关系：方法：在PubMed和Embase中检索了2001-2021年间所有关于视网膜血管口径与CHD和CHD危险因素关系的观察性研究。该荟萃分析已在 PROSPERO 注册（注册号为 CRD42021267154）：结果：共有 14 篇文章被选入此次荟萃分析。在主要结果中，视网膜小动脉口径与冠心病有关，结果具有统计学意义（MD：-5.55，95% CI：-8.07 至 -3.02，p < 0.0001），而冠心病患者和健康人的静脉口径没有显著差异（MD：1.10，95% CI：-3.55 至 5.76，p = 0.64 > 0.05）。视网膜动脉直径较小与年龄增长、男性、体重指数较大和高血压有关。视网膜动脉口径变大与吸烟有关。视网膜静脉口径较小与年龄增长和高血压有关。视网膜静脉口径变大与吸烟、体重指数（BMI）变大和糖尿病有关：结论：视网膜动静脉口径较小与心脏病有关，而心脏病患者和健康人的视网膜静脉口径没有显著差异。视网膜血管口径还与心脏病风险因素（如年龄、性别、吸烟、体重指数、高血压和糖尿病）独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.