Moderating effect of bone maturation on the relationship between body fat and insulin resistance.

IF 1
Luis Flores, Isabel Fragoso, Lidia G De León, Briseidy Ortiz-Rodríguez, Ramón Candia-Luján, Claudia Carrasco-Legleu
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Abstract

Objectives: The aim of the present study was to analyze the moderating effect of maturation on the relationship between body fat and insulin resistance, in children from 9 to 12 years.

Methods: Maturity offset, homeostasis model assessment index of insulin resistance (HOMA-IR), and body fat percentage (BF%) were estimated in 127 children. Skeletal maturation indicator (SMI) was estimated in 105 participants. A moderation analysis based on a linear regression and on Johnson-Neyman technique was performed using a 95% confidence level.

Results: BF%, insulin levels, and HOMA-IR values were lower in late maturers than on-time maturers (p<0.05). SMI moderated the relationship between BF% and HOMA-IR index in 11.1% of boys and in 32.5% of girls (p<0.05). Also, the highest values of HOMA-IR index were observed at -1 year to achieve the peak height velocity, in girls (p<0.05).

Conclusions: Maturation process has a moderation effect on the relationship BF% and insulin resistance, particularly in early maturers; furthermore, it was independently associated with HOMA-IR.

骨成熟对体脂与胰岛素抵抗关系的调节作用。
目的:本研究的目的是分析成熟对9至12岁儿童体脂和胰岛素抵抗之间关系的调节作用。方法:对127例儿童进行成熟度偏移、胰岛素抵抗稳态模型评估指数(HOMA-IR)和体脂率(BF%)的测定。评估了105名参与者的骨骼成熟指标(SMI)。采用线性回归和Johnson-Neyman技术进行调节分析,置信水平为95%。结果:晚熟者的BF%、胰岛素水平和HOMA-IR值低于准时成熟者(结论:成熟过程对BF%和胰岛素抵抗的关系有调节作用,尤其是在早熟者中;此外,它与HOMA-IR独立相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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