Urologic characteristics and sexual behaviors associated with prostate cancer in an african-Caribbean population in barbados, west indies.

IF 2.3 Q3 ONCOLOGY

Prostate Cancer Pub Date : 2013-01-01 Epub Date: 2013-02-25 DOI:10.1155/2013/682750

Anselm J M Hennis, Suh-Yuh Wu, Barbara Nemesure, M Cristina Leske

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Abstract

Prostate cancer (PC) is the principal malignancy affecting African descent men in the Caribbean and the USA. Disparities in incidence, prevalence, and mortality in these populations are poorly understood. We evaluated the urologic characteristics and sexual behaviors of men with histologically confirmed PC (cases) and age-matched controls in the nationwide Prostate Cancer in a Black Population (PCBP) study conducted in Barbados. Cases were around 1.5 to 3 times more likely to report symptoms of prostatic enlargement, hematuria/hematospermia, and previous prostatitis. Sexually transmitted infections (STIs) were similar among cases (24.5%) and controls (26.7%). First sexual intercourse before the age of 16 was associated with an increased likelihood of both low- (Gleason score < 7; OR 1.63; 95% CI: 1.03-1.66) and high-grade PC (Gleason score ≥ 7; OR 1.82; 1.11-2.99). PC risk decreased with later age of sexual debut (P-trend = 0.004). More lifetime sexual partners was associated with increased odds of high grade PC (P-trend = 0.02). The contribution of sexual behaviors to the development and the outcomes of PC is likely due to multiple mechanisms, and further study will be necessary to elucidate the underlying pathophysiologic mechanisms in this and similar populations.

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西印度群岛巴巴多斯非洲-加勒比人口中与前列腺癌相关的泌尿系统特征和性行为。

前列腺癌（PC）是影响加勒比海地区和美国非洲裔男性的主要恶性肿瘤。人们对这些人群在发病率、患病率和死亡率方面的差异知之甚少。在巴巴多斯进行的全国性黑人前列腺癌（PCBP）研究中，我们评估了经组织学证实患有前列腺癌的男性（病例）和年龄匹配的对照组的泌尿系统特征和性行为。病例报告前列腺增生、血尿/血精和既往前列腺炎症状的几率大约是对照组的 1.5 到 3 倍。性传播感染（STI）在病例（24.5%）和对照组（26.7%）中的比例相似。16 岁前首次性交与低度 PC（Gleason 评分<7；OR 1.63；95% CI：1.03-1.66）和高度 PC（Gleason 评分≥7；OR 1.82；1.11-2.99）的可能性增加有关。PC风险随着初次性行为年龄的推迟而降低（P-趋势 = 0.004）。终生性伴侣越多，患高级别 PC 的几率越高（P-趋势 = 0.02）。性行为对 PC 的发生和结果的影响可能是由多种机制造成的，因此有必要进行进一步研究，以阐明该人群及类似人群的潜在病理生理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostate Cancer ONCOLOGY-

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Prostate Cancer is a peer-reviewed, Open Access journal that provides a multidisciplinary platform for scientists, surgeons, oncologists and clinicians working on prostate cancer. The journal publishes original research articles, review articles, and clinical studies related to the diagnosis, surgery, radiotherapy, drug discovery and medical management of the disease.