The Modified Glasgow Prognostic Score Predicts Survival in Gastric Cancer Patients with Normal CEA and CA19-9.

IF 2.7 4区医学 Q2 Medicine

Canadian Journal of Gastroenterology and Hepatology Pub Date : 2022-06-13 eCollection Date: 2022-01-01 DOI:10.1155/2022/3953004

Shun Zhang, Jing-Ze Li, Tao Du, Hai-Qiang Li, Ren-Hao Hu, Chi-Ye Ma, Xi-Mao Cui, Chun Song, Xiao-Hua Jiang

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引用次数: 5

Abstract

Background: Traditionally, serum CEA and CA19-9 levels are good prognostic factors for gastric cancer. Many gastric cancer patients do not have elevated CEA or CA19-9 levels even at a very advanced stage. This study investigates the significance of the modified Glasgow prognostic score (mGPS) for the survival of gastric cancer patients with normal CEA and CA19-9.

Methods: We retrospectively examined 488 curatively resected gastric cancer patients with normal preoperative serum levels of CEA and CA19-9 to evaluate the prognostic ability of mGPS for overall survival. The prognostic significance was analyzed by univariate and multivariate analyses.

Results: Age, hemoglobin, white cell count, and neutrophils were each significantly correlated with the mGPS. Multivariate analyses showed that tumor location (HR, 0.803; 95% CI, 0.667-0.966; P=0.020), TNM stage (HR, 2.714; 95% CI, 2.250-3.275; P < 0.001), and mGPS (HR, 1.042; 95% CI, 1.105-1.772; P=0.023) were significantly associated with overall survival. Significant correlations were found between overall survival and mGPS. The Kaplan-Meier analysis demonstrated significant differences among patients with mGPS of 0, 1, and 2 (P < 0.001), with the mortality rate being higher for patients with a higher mGPS.

Conclusion: The mGPS can predict survival in gastric cancer patients with normal CEA and CA19-9.

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改良格拉斯哥预后评分预测CEA和CA19-9正常胃癌患者的生存。

背景:传统上，血清CEA和CA19-9水平是胃癌预后的良好指标。许多胃癌患者即使在非常晚期也没有CEA或CA19-9水平升高。本研究探讨改良格拉斯哥预后评分(mGPS)对CEA和CA19-9正常胃癌患者生存的意义。方法:回顾性分析488例胃癌根治患者，术前血清CEA和CA19-9水平正常，评价mGPS对总生存期的预后能力。采用单因素和多因素分析对预后意义进行分析。结果:年龄、血红蛋白、白细胞计数、中性粒细胞与mGPS均有显著相关。多因素分析显示，肿瘤位置(HR, 0.803;95% ci, 0.667-0.966;P=0.020)、TNM分期(HR, 2.714;95% ci, 2.250-3.275;P < 0.001)， mGPS (HR, 1.042;95% ci, 1.105-1.772;P=0.023)与总生存率显著相关。总生存率与mGPS之间存在显著相关性。Kaplan-Meier分析显示mGPS为0、1和2的患者之间存在显著差异(P < 0.001)， mGPS较高的患者死亡率更高。结论:mGPS可预测CEA和CA19-9正常的胃癌患者的生存。

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来源期刊

Canadian Journal of Gastroenterology and Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

37 weeks

期刊介绍： Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.