{"title":"Can mesenchymal stem cells derived from adipose tissue and their conditioned medium improve ovarian functions? A mini-review.","authors":"Tayebe Pouryousefi-Koodehi, Shika Shayegan, Soheyla Hashemi, Reza Arefnezhad, Hossein Roghani-Shahraki, Hossein Motedayyen, Neda Taghizabet, Fatemeh Rezaei-Tazangi","doi":"10.1017/S0967199422000235","DOIUrl":null,"url":null,"abstract":"<p><p>Stable ovarian function is a key factor in the performance of the reproductive system. In contrast, some ovarian function-related diseases, such as polycystic ovarian syndrome, premature ovarian failure (POF), and ovarian cancer, are the main cause of infertility and death of women around the world. Despite multiple attempts, there are no effective tools against these conditions; however, mesenchymal stem cell-based therapy, especially using adipose tissue, has attracted much attention in medicine in light of its advantages such as easy isolation and accessibility. Conversely, it has been suggested that MSC-conditioned medium (CM) can restore injured tissues and has high immunocompatibility. So, here, we will summarize the effects of administration of MSCs and CM derived from adipose tissue on ovarian functions and related diseases.</p>","PeriodicalId":136608,"journal":{"name":"Zygote (Cambridge, England)","volume":" ","pages":"589-592"},"PeriodicalIF":0.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zygote (Cambridge, England)","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1017/S0967199422000235","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/6/22 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
Stable ovarian function is a key factor in the performance of the reproductive system. In contrast, some ovarian function-related diseases, such as polycystic ovarian syndrome, premature ovarian failure (POF), and ovarian cancer, are the main cause of infertility and death of women around the world. Despite multiple attempts, there are no effective tools against these conditions; however, mesenchymal stem cell-based therapy, especially using adipose tissue, has attracted much attention in medicine in light of its advantages such as easy isolation and accessibility. Conversely, it has been suggested that MSC-conditioned medium (CM) can restore injured tissues and has high immunocompatibility. So, here, we will summarize the effects of administration of MSCs and CM derived from adipose tissue on ovarian functions and related diseases.
稳定的卵巢功能是生殖系统性能的关键因素。相比之下，一些与卵巢功能有关的疾病，如多囊卵巢综合征、卵巢早衰(POF)和卵巢癌，是世界各地妇女不孕和死亡的主要原因。尽管进行了多次尝试，但没有针对这些情况的有效工具;然而，基于间充质干细胞的治疗，特别是利用脂肪组织的治疗，因其易于分离和获取等优点而受到医学界的广泛关注。相反，有研究表明，MSC-conditioned medium (CM)可以修复损伤组织，并且具有较高的免疫相容性。因此，在这里，我们将总结脂肪组织来源的MSCs和CM对卵巢功能和相关疾病的影响。
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