Comparison of clonidine and midazolam as anxiolytic premedication before wisdom tooth surgery: a randomized, double-blind, crossover pilot study.

Oral and maxillofacial surgery Pub Date : 2012-12-01 Epub Date: 2012-03-13 DOI:10.1007/s10006-012-0319-8

Franziska R Studer, Klaus W Grätz, Till S Mutzbauer

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引用次数: 14

Abstract

Purpose: Anxiolytic and possible side effects of clonidine 150 μg compared to midazolam 7.5 mg for premedication in surgical wisdom tooth extraction were evaluated.

Methods: In a prospective, randomized, double-blind crossover trial, ten patients undergoing bilateral wisdom tooth surgery received clonidine or midazolam orally 1 h before the treatment. Patients receiving midazolam for the first surgery received clonidine at the second surgery and vice versa. The anxiolytic efficacy was evaluated with a visual analogue scale (VAS) upon admission and 30, 50 and 60 min after administration of the medication. Patient satisfaction was recorded on a VAS after surgery and 7 days postoperatively.

Results: As soon as 30 min after administration of midazolam (p < 0.03) and clonidine (p < 0.02), an anxiolytic effect was recorded. Both medications did not differ in patient satisfaction.

Conclusion: Oral administration of clonidine 150 μg and midazolam 7.5 mg were rated as medications with equal anxiolytic effects before wisdom tooth surgery under local anesthesia.

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可乐定和咪达唑仑作为智齿手术前抗焦虑药物的比较:一项随机、双盲、交叉先导研究。

目的:比较150 μg可乐定与7.5 mg咪达唑仑在智齿拔除手术用药前的抗焦虑作用及可能的副作用。方法:在一项前瞻性、随机、双盲交叉试验中，10例双侧智齿手术患者在治疗前1小时口服可乐定或咪达唑仑。在第一次手术中使用咪达唑仑的患者在第二次手术中使用可乐定，反之亦然。采用视觉模拟评分法(VAS)评价患者入院时及给药后30min、50min和60min的抗焦虑效果。术后及术后7天通过VAS记录患者满意度。结论:局麻下智齿手术前口服可乐定150 μg与口服咪达唑仑7.5 mg具有同等的抗焦虑作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Oral and maxillofacial surgery

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