Commentary regarding recent Million Women Study critique and subsequent publicity.

Abstract

of critique The Million Women Study (MWS) was one of the major studies that raised concerns over the long-term safety of hormone replacement therapy (HRT). Shapiro et al. applied causal criteria, such as biases and biological plausibility, to assess the MWS findings. Their analysis highlighted several design flaws that would potentially have skewed the findings; the key criticisms of the MWS design were as follows: