Designing a 'neotissue' using the principles of biology, chemistry and engineering.

Q4 Biochemistry, Genetics and Molecular Biology
Journal of Stem Cells Pub Date : 2012-01-01
Madhusudhan Nannaparaju, Emeka Oragui, Wasim S Khan
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引用次数: 0

Abstract

The traditional methods of treating musculoskeletal injuries and disorders are not completely effective and have several limitations. Tissue engineering involves using the principles of biology, chemistry and engineering to design a 'neotissue' that augments a malfunctioning in vivo tissue. The main requirements for functional engineered tissue include reparative cellular components that proliferate on a scaffold grown within a bioreactor that provides specific biochemical and physical signals to regulate cell differentiation and tissue assembly. In this review we provide an overview of the biology of common musculoskeletal tissue and discuss their common pathologies. We also describe the commonly used stem cells, scaffolds and bioreactors and evaluate their role in issue engineering.

利用生物学、化学和工程学原理设计一个“新组织”。
传统的治疗肌肉骨骼损伤和疾病的方法并不完全有效,并且有一些局限性。组织工程涉及到使用生物学、化学和工程学的原理来设计一个“新组织”,以增加体内组织的故障。功能性工程组织的主要需求包括在生物反应器中生长的支架上增殖的修复细胞成分,该支架提供特定的生化和物理信号来调节细胞分化和组织组装。在这篇综述中,我们提供了常见的肌肉骨骼组织的生物学的概述,并讨论其常见的病理。我们还介绍了常用的干细胞、支架和生物反应器,并评价了它们在问题工程中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Stem Cells
Journal of Stem Cells Medicine-Transplantation
CiteScore
0.10
自引率
0.00%
发文量
1
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