{"title":"Mean nuclear volume in complex atypical hyperplasia and adenocarcinoma of the endometrium.","authors":"Jasleen Kaur, Pranab Dey","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the possible role of mean nuclear volume (MNV) in differentiating complex atypical hyperplasia (CAH) from well-differentiated adenocarcinoma (WDAC) of the endometrium.</p><p><strong>Study design: </strong>In this retrospective study we measured MNV in 15 cases each of CAH and WDAC using the point intercepts method. At least 100 nuclei were selected for MNV estimation in each case.</p><p><strong>Results: </strong>The mean MNV in CAH was 430.06 microm3 (SD 232.43); the MNV in WDAC was 753.14 microm3 (SD 322.87). Independent sample t test showed significant difference (p < 0.005) of MNV between CAH and WDAC.</p><p><strong>Conclusion: </strong>MNV determination resulted in a wide-ranging overlap of distributions for CAH and WDAC cases, such that at best only a modest proportion of cases with very low MNV values offer a diagnostic clue.</p>","PeriodicalId":76995,"journal":{"name":"Analytical and quantitative cytology and histology","volume":" ","pages":"291-4"},"PeriodicalIF":0.0000,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and quantitative cytology and histology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To explore the possible role of mean nuclear volume (MNV) in differentiating complex atypical hyperplasia (CAH) from well-differentiated adenocarcinoma (WDAC) of the endometrium.
Study design: In this retrospective study we measured MNV in 15 cases each of CAH and WDAC using the point intercepts method. At least 100 nuclei were selected for MNV estimation in each case.
Results: The mean MNV in CAH was 430.06 microm3 (SD 232.43); the MNV in WDAC was 753.14 microm3 (SD 322.87). Independent sample t test showed significant difference (p < 0.005) of MNV between CAH and WDAC.
Conclusion: MNV determination resulted in a wide-ranging overlap of distributions for CAH and WDAC cases, such that at best only a modest proportion of cases with very low MNV values offer a diagnostic clue.
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