Usefulness and limitations of alpha-methylacyl-CoA racemase expression in the hepatobiliary system and pancreas: a wide tissue microarray analysis of normal and neoplastic epithelia.

Analytical and quantitative cytology and histology Pub Date : 2010-10-01

Ana Mozos, Manel Sole, Rosa Miquel, Ana Petit, Alfons Nadal, Pedro Luis Fernández

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Abstract

Objective: To establish the frequency, significance and clinical utility of alpha-methylacyl-CoA racemase (AMACR) expression in the hepatobiliary system by performing a wide immunohistochemical screening of AMACR expression.

Study design: A total of 204 neoplastic, preneoplastic and normal samples from the hepatobiliary and pancreatic system were immunohistochemically studied on tissue microarrays for AMACR expression and correlated with clinicopathologic parameters.

Results: Hepatocellular carcinomas (HCC) showed intense AMACR expression, which was significantly stronger than in nonmalignant tissues and correlated with good differentiation but not with evolution. Weak AMACR expression was observed in cholangiocarcinomas and preneoplastic pancreatic lesions. HCC showed stronger expression than cholangiocarcinomas and ductal pancreatic adenocarcinomas.

Discussion: AMACR is strongly expressed in some neoplastic and preneoplastic lesions of the hepatobiIiary system, mainly HCC, and may play a role in malignant transformation and be useful in the differential diagnosis.

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-甲基酰基辅酶a消消酶在肝胆系统和胰腺中的表达的有效性和局限性:正常和肿瘤上皮的广泛组织微阵列分析。

目的:通过对α -甲基酰基辅酶a消消酶(AMACR)表达进行广泛的免疫组化筛选，探讨其在肝胆系统中的表达频率、意义及临床应用价值。研究设计:采用组织芯片对204例来自肝胆胰系统的肿瘤、肿瘤前和正常样本进行了AMACR表达的免疫组织化学研究，并与临床病理参数进行了相关研究。结果:肝细胞癌(HCC)中AMACR表达强烈，明显强于非恶性组织，且与良好分化相关，但与进化无关。在胆管癌和胰腺癌前病变中，AMACR表达较弱。肝细胞癌的表达强于胆管癌和胰管腺癌。讨论:AMACR在肝胆道系统的一些肿瘤和肿瘤前病变中强烈表达，主要是HCC，可能在恶性转化中起作用，并可用于鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Analytical and quantitative cytology and histology

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