Prognostic significance of p53 and KAI-1 expression in patients with laryngeal squamous cell carcinoma.

Analytical and quantitative cytology and histology Pub Date : 2010-10-01

Massimo Re, Giuseppe Magliulo, Eleonora Salvolini, Monia Orciani, Federico Maria Gioacchini, Gaia Goteri, Corrado Rubini

{"title":"Prognostic significance of p53 and KAI-1 expression in patients with laryngeal squamous cell carcinoma.","authors":"Massimo Re, Giuseppe Magliulo, Eleonora Salvolini, Monia Orciani, Federico Maria Gioacchini, Gaia Goteri, Corrado Rubini","doi":"","DOIUrl":null,"url":null,"abstract":"Objective: To examine the prognostic significance of the immunohistochemical expression of p53 and KAI-1 oncoproteins in patients with laryngeal squamous cell carcinoma.Study design: A retrospective evaluation was developed on 82 patients with primary laryngeal squamous cell carcinoma treated by primary surgery. For the immunohistochemical evaluation, formalin-fixed and paraffin-embedded tissue blocks from resection were used. Clinicopathologic data were correlated with the staining results.Results: The results of the immunohistochemical examination showed a statistically significant relationship between down-regulation of KAI-1 protein expression, increase of the histologic grading, and primary tumors associated with lymph node metastases. On the other hand, no statistical correlation was evidenced between p53 up-regulation and clinicopathologic data or between the two markers.Conclusion: Our results suggest that KAI-1 may become an important biomarker that could help in selection of high-risk patients with laryngeal squamous cell carcinoma who may benefit from more aggressive therapy or chemoprevention.","PeriodicalId":76995,"journal":{"name":"Analytical and quantitative cytology and histology","volume":" ","pages":"247-53"},"PeriodicalIF":0.0000,"publicationDate":"2010-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and quantitative cytology and histology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To examine the prognostic significance of the immunohistochemical expression of p53 and KAI-1 oncoproteins in patients with laryngeal squamous cell carcinoma.

Study design: A retrospective evaluation was developed on 82 patients with primary laryngeal squamous cell carcinoma treated by primary surgery. For the immunohistochemical evaluation, formalin-fixed and paraffin-embedded tissue blocks from resection were used. Clinicopathologic data were correlated with the staining results.

Results: The results of the immunohistochemical examination showed a statistically significant relationship between down-regulation of KAI-1 protein expression, increase of the histologic grading, and primary tumors associated with lymph node metastases. On the other hand, no statistical correlation was evidenced between p53 up-regulation and clinicopathologic data or between the two markers.

Conclusion: Our results suggest that KAI-1 may become an important biomarker that could help in selection of high-risk patients with laryngeal squamous cell carcinoma who may benefit from more aggressive therapy or chemoprevention.

本刊更多论文

p53和KAI-1表达在喉鳞癌患者中的预后意义。

目的:探讨喉鳞癌患者p53和KAI-1癌蛋白免疫组化表达对预后的影响。研究设计:回顾性分析82例经手术治疗的原发性喉部鳞状细胞癌患者。免疫组织化学评价采用福尔马林固定和石蜡包埋的切除组织块。临床病理资料与染色结果相关。结果:免疫组化检查结果显示KAI-1蛋白表达下调、组织学分级升高与原发肿瘤伴淋巴结转移有统计学意义。另一方面，p53上调与临床病理数据或两者之间没有统计学相关性。结论:我们的研究结果表明KAI-1可能成为一个重要的生物标志物，可以帮助选择高风险的喉鳞癌患者，这些患者可能受益于更积极的治疗或化学预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Analytical and quantitative cytology and histology

自引率

0.00%

发文量