The role of phospholipase A2-derived mediators in obesity

Abstract

Obesity has become an epidemic and its prevalence is increasing exponentially. A great deal of focus has been given to understanding the molecular processes that regulate obesity. The characterization of phospholipase A₂s, especially adipose-specific PLA₂, has lead to a proposed role of their downstream products in the progression of obesity and obesity related disorders. This review summarizes recent developments in the role of PLA₂ and their downstream effects in the development of metabolic disorders.