The synthesis of Aspirin and Acetobromo-α-D-glucose using 3D printed flow reactors: an undergraduate demonstration

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Oyekunle Azeez Alimi, Kariska Potgieter, Aisha A. Khumalo, Kgabo Zwane, Lesiba S.M. Mashishi, Odirile G. Gaborone, Reinout Meijboom
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引用次数: 0

Abstract

The field of flow chemistry is growing rapidly, drawing attention across different disciplines. Despite its increasing popularity in the industry and research, little attention is given to the teaching of flow chemistry in the educational environment, especially at the undergraduate level. A major challenge with teaching undergraduate flow chemistry is the high cost of flow chemistry equipment. This study reports the development of low-cost, functioning flow chemistry equipment for the teaching of flow chemistry and experimental practicum. This provides the students with hands-on instruction in fabricating flow reaction devices by 3D printing. It also allows undergraduate students to understand the basics of flow chemistry and chemical engineering. An exciting part of this study is the skills acquired by undergraduate students. This is because of the learning experience they are exposed to by training and independently operating fabrication equipment, setting up flow experiments and conducting flow experiments with the fabricated devices. Finally, due to the low cost of the equipment, the set-up is suitable for teaching flow chemistry in a low-resource environment, such as our teaching laboratories in South Africa.

Graphical abstract

Abstract Image

利用3D打印流动反应器合成阿司匹林和乙酰溴-α- d -葡萄糖:大学生示范
流动化学领域正在迅速发展,引起了不同学科的关注。尽管流动化学在工业界和研究界越来越受欢迎,但在教育环境中,特别是在本科阶段,很少有人关注它的教学。流动化学本科教学面临的主要挑战是流动化学设备的高成本。本文报道了一种低成本、功能齐全的流动化学设备的研制,用于流动化学教学和实验实习。这为学生提供了通过3D打印制造流动反应装置的动手指导。它还允许本科生了解流动化学和化学工程的基础知识。这项研究的一个令人兴奋的部分是大学生获得的技能。这是因为他们通过培训和独立操作制造设备,设置流动实验并使用制造设备进行流动实验而获得的学习经验。最后,由于设备成本低,该设置适合在资源匮乏的环境中进行流化学教学,例如我们在南非的教学实验室。图形抽象
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来源期刊
Journal of Flow Chemistry
Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
6.40
自引率
3.70%
发文量
29
审稿时长
>12 weeks
期刊介绍: The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.
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