{"title":"Sorafenib in hepatocellular carcinoma.","authors":"Debra H Josephs, Paul J Ross","doi":"10.12968/hmed.2010.71.8.77669","DOIUrl":null,"url":null,"abstract":"<p><p>Sorafenib, a small molecule multikinase inhibitor, is the standard of care in the USA and Europe for the treatment of advanced hepatocellular carcinoma. This article reviews its development from the basis of molecular hepatocarcinogenesis to phase III trials and discusses the future for sorafenib in hepatocellular carcinoma.</p>","PeriodicalId":520576,"journal":{"name":"British journal of hospital medicine (London, England : 2005)","volume":" ","pages":"451-6"},"PeriodicalIF":1.8000,"publicationDate":"2010-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.12968/hmed.2010.71.8.77669","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"British journal of hospital medicine (London, England : 2005)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12968/hmed.2010.71.8.77669","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 7
Abstract
Sorafenib, a small molecule multikinase inhibitor, is the standard of care in the USA and Europe for the treatment of advanced hepatocellular carcinoma. This article reviews its development from the basis of molecular hepatocarcinogenesis to phase III trials and discusses the future for sorafenib in hepatocellular carcinoma.