Continuum model of mechanical interactions between biological cells and artificial nanostructures.

IF 2.1 4区医学 Q2 Physics and Astronomy

Biointerphases Pub Date : 2010-06-01 DOI:10.1116/1.3431960

Piyush Verma, Ian Y Wong, Nicholas A Melosh

引用次数: 19

Abstract

The controlled insertion of artificial nanostructures into biological cells has been utilized for patch clamping, targeted drug delivery, cell lysing, and cell mechanics measurements. In this work, an elastic continuum model is implemented to treat the deformation of spherical cells in solution due to their interaction with cylindrical probes. At small deformations, the force varies nonlinearly with indentation due to global deformation of the cell shape. However, at large indentations, the force varies linearly with indentation due to more localized deformations. These trends are consistent with experimental measurements under comparable conditions and can be used to develop design rules for optimizing probe-cell interactions.

查看原文本刊更多论文

生物细胞与人造纳米结构之间力学相互作用的连续体模型。

人工纳米结构在生物细胞中的控制插入已被用于贴片夹紧、靶向药物递送、细胞裂解和细胞力学测量。在这项工作中，采用弹性连续体模型来处理球形细胞在溶液中由于与圆柱形探针的相互作用而产生的变形。在小变形时，由于单元形状的整体变形，力随压痕非线性变化。然而，在较大的压痕下，由于更多的局部变形，力随压痕线性变化。这些趋势与可比条件下的实验测量结果一致，可用于制定优化探针-细胞相互作用的设计规则。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biointerphases BIOPHYSICS-MATERIALS SCIENCE, BIOMATERIALS

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biointerphases emphasizes quantitative characterization of biomaterials and biological interfaces. As an interdisciplinary journal, a strong foundation of chemistry, physics, biology, engineering, theory, and/or modelling is incorporated into originated articles, reviews, and opinionated essays. In addition to regular submissions, the journal regularly features In Focus sections, targeted on specific topics and edited by experts in the field. Biointerphases is an international journal with excellence in scientific peer-review. Biointerphases is indexed in PubMed and the Science Citation Index (Clarivate Analytics). Accepted papers appear online immediately after proof processing and are uploaded to key citation sources daily. The journal is based on a mixed subscription and open-access model: Typically, authors can publish without any page charges but if the authors wish to publish open access, they can do so for a modest fee. Topics include: bio-surface modification nano-bio interface protein-surface interactions cell-surface interactions in vivo and in vitro systems biofilms / biofouling biosensors / biodiagnostics bio on a chip coatings interface spectroscopy biotribology / biorheology molecular recognition ambient diagnostic methods interface modelling adhesion phenomena.