Hiding in plain sight: three chemically distinct α-helix types.

IF 7.2 2区生物学 Q1 BIOPHYSICS

Quarterly Reviews of Biophysics Pub Date : 2022-06-20 DOI:10.1017/S0033583522000063

Shuguang Zhang, Martin Egli

引用次数: 4

Abstract

Linus Pauling in 1950 published a three-dimensional model for a universal protein secondary structure motif which he initially called the alpha-spiral. Jack Dunitz, then a postdoc in Pauling's lab suggested to Pauling that the term helix is more accurate than spiral when describing the right-handed peptide and protein coiled structures. Pauling agreed, hence the rise of the alpha-helix, and, by extension, the ‘double helix’ structure of DNA. Although structural biologists and protein chemists are familiar with varying polar and apolar characters of amino acids in alpha-helices, to non-experts the three chemically distinct alpha-helix types classified here may hide in plain sight.

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隐藏在显而易见的:三种化学上不同的α-螺旋型。

1950年，莱纳斯·鲍林(Linus Pauling)发表了一个通用蛋白质二级结构基序的三维模型，他最初称之为α -螺旋。杰克·杜尼茨当时是鲍林实验室的博士后，他向鲍林建议，在描述右旋肽和蛋白质盘绕结构时，“螺旋”一词比“螺旋”更准确。鲍林同意了，因此出现了α -螺旋结构，并引申为DNA的“双螺旋”结构。虽然结构生物学家和蛋白质化学家对α -螺旋中氨基酸的极性和极性特征都很熟悉，但对于非专家来说，这里分类的三种化学上不同的α -螺旋类型可能是显而易见的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quarterly Reviews of Biophysics 生物-生物物理

CiteScore

12.90

自引率

1.60%

发文量

期刊介绍： Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.