Increased level of hepatocyte growth factor in children with dengue virus infection.

Annals of Tropical Paediatrics Pub Date : 2010-01-01 DOI:10.1179/146532810X12786388978607

N Voraphani, A Theamboonlers, A Khongphatthanayothin, C Srisai, Y Poovorawan

{"title":"Increased level of hepatocyte growth factor in children with dengue virus infection.","authors":"N Voraphani, A Theamboonlers, A Khongphatthanayothin, C Srisai, Y Poovorawan","doi":"10.1179/146532810X12786388978607","DOIUrl":null,"url":null,"abstract":"Background: Evidence of hepatocellular damage is common in dengue-infected individuals. Hepatocyte growth factor (HGF), a key cytokine responsible for liver regeneration, may play a prognostic role in dengue virus infection.Aim: To determine the relationship between serum HGF level and disease severity in patients with dengue virus infection.Methods: Serum samples from 27 children [17 dengue fever (DF), ten dengue haemorrhagic fever (DHF)] with serologically confirmed dengue virus infection during the febrile, toxic stages and at follow-up were analysed for HGF. Serum samples obtained from nine healthy children served as the control group.Results: In dengue-infected patients, serum HGF was significantly higher at the febrile and toxic stages than at follow-up (p<0.05). In comparison with DF, patients with DHF had a greater level of HGF at the febrile stage (p<0.05). A cut-off HGF level of 1220 pg/mL obtained during the febrile stage showed a sensitivity of 90% and a specificity of 53% for predicting clinical progression to DHF (area under the ROC curve 0.75).Conclusion: Serum HGF level at the early stage of dengue virus infection is elevated and may be a useful predictor for clinical progression to DHF.","PeriodicalId":50759,"journal":{"name":"Annals of Tropical Paediatrics","volume":"30 3","pages":"213-8"},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1179/146532810X12786388978607","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Tropical Paediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1179/146532810X12786388978607","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 13

Abstract

Background: Evidence of hepatocellular damage is common in dengue-infected individuals. Hepatocyte growth factor (HGF), a key cytokine responsible for liver regeneration, may play a prognostic role in dengue virus infection.

Aim: To determine the relationship between serum HGF level and disease severity in patients with dengue virus infection.

Methods: Serum samples from 27 children [17 dengue fever (DF), ten dengue haemorrhagic fever (DHF)] with serologically confirmed dengue virus infection during the febrile, toxic stages and at follow-up were analysed for HGF. Serum samples obtained from nine healthy children served as the control group.

Results: In dengue-infected patients, serum HGF was significantly higher at the febrile and toxic stages than at follow-up (p<0.05). In comparison with DF, patients with DHF had a greater level of HGF at the febrile stage (p<0.05). A cut-off HGF level of 1220 pg/mL obtained during the febrile stage showed a sensitivity of 90% and a specificity of 53% for predicting clinical progression to DHF (area under the ROC curve 0.75).

Conclusion: Serum HGF level at the early stage of dengue virus infection is elevated and may be a useful predictor for clinical progression to DHF.

查看原文本刊更多论文

登革病毒感染儿童肝细胞生长因子水平升高。

背景:肝细胞损伤的证据在登革热感染者中很常见。肝细胞生长因子(HGF)是负责肝脏再生的关键细胞因子，可能在登革热病毒感染中发挥预后作用。目的:探讨登革热病毒感染患者血清HGF水平与病情严重程度的关系。方法:对27例经血清学证实登革热病毒感染的儿童[17例登革热(DF)， 10例登革出血热(DHF)]在发热期、中毒期及随访期间的血清进行HGF分析。选取9名健康儿童血清作为对照组。结果:在登革热感染患者中，血清HGF在发热期和中毒期明显高于随访期(结论:登革热病毒感染早期血清HGF水平升高，可能是DHF临床进展的有用预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of Tropical Paediatrics 医学-热带医学

自引率

0.00%

发文量

审稿时长

>12 weeks