Analysis of the characteristics of patients with false-positive HIV screening assay results

IF 4.7 2区医学 Q2 IMMUNOLOGY

International immunopharmacology Pub Date : 2022-04-01 DOI:10.1016/j.intimp.2022.108556

Yi-Qiang Lin , Ya-Ling Gao , Mao Wang , Shui-Di Yan , Li-Rong Lin

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引用次数: 2

Abstract

Objective

To investigate the clinical characteristics of patients with false-positive human immunodeficiency virus (HIV) screening test results and provide a theoretical basis to interpret the results of HIV screening tests.

Methods

This retrospective study evaluated the incidence of false-positive results for HIV screening tests and characterized false-positive reactions during HIV screening in a large-scale study at Zhongshan Hospital, Xiamen University.

Results

False-positive HIV test results occurred for 264 of 275,263 (0.10%) serum samples. Although the incidence of a false-positive HIV screening result did not differ between male and female patients (screening χ² = 1.194; P = 0.275), it increased with age (χ² = 25.759; P < 0.01). False-positive reactions were associated with 16 disease categories, including 101 diseases, some of which have never been reported previously to be associated with false-positive HIV screening results.

Conclusions

The occurrence of false-positive HIV screening test results may indicate underlying serious disorders. Characterization of patients with false-positive HIV screening test results can help identify potential diseases unrelated to HIV.

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HIV筛查结果假阳性患者特点分析

目的探讨人类免疫缺陷病毒(HIV)筛查结果假阳性患者的临床特点，为解读HIV筛查结果提供理论依据。方法回顾性分析厦门大学附属中山医院HIV筛查假阳性结果的发生率，分析HIV筛查假阳性反应。结果275263份血清中有264份HIV假阳性，占0.10%。尽管HIV筛查假阳性的发生率在男性和女性患者之间没有差异(筛查χ2 = 1.194;P = 0.275)，随年龄增长而增高(χ2 = 25.759;P & lt;0.01)。假阳性反应与16种疾病有关，其中包括101种疾病，其中一些疾病以前从未报告与艾滋病毒假阳性筛查结果有关。结论HIV筛查结果出现假阳性可能提示潜在的严重疾病。对艾滋病毒筛查结果假阳性的患者进行特征描述有助于识别与艾滋病毒无关的潜在疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.