Clinical Features of COVID-19 Patients in the First Year of Pandemic: A Systematic Review and Meta-Analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-04-01 Epub Date: 2021-12-04 DOI:10.1177/10998004211055866

Mohammed Al Maqbali, Khalid Al Badi, Mohammed Al Sinani, Norah Madkhali, Geoffrey L Dickens

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引用次数: 10

Abstract

Background: The new coronavirus disease (COVID-19) carries a high risk of infection and has spread rapidly around the world. However, there are limited data about the clinical symptoms globally. The purpose of this systematic review and meta-analysis is to identify the prevalence of the clinical symptoms of patient with COVID-19.

Methods: A systematic review and meta-analysis were carried out. The following databases were searched: PubMed, CINAHL, MEDLINE, EMBASE, PsycINFO, medRxiv, and Google Scholar, from December 1st, 2019 to January 1st, 2021. Prevalence rates were pooled with meta-analysis using a random-effects model. Heterogeneity was tested using I-squared (I²) statistics.

Results: A total of 215 studies, involving 132,647 COVID-19 patients, met the inclusion criteria. The pooled prevalence of the four most common symptoms were fever 76.2% (n = 214; 95% CI 73.9-78.5); coughing 60.4% (n = 215; 95% CI 58.6-62.1); fatigue 33.6% (n = 175; 95% CI 31.2-36.1); and dyspnea 26.2% (n = 195; 95% CI 24.1-28.5). Other symptoms from highest to lowest in terms of prevalence include expectorant (22.2%), anorexia (21.6%), myalgias (17.5%), chills (15%), sore throat (14.1%), headache (11.7%), nausea or vomiting (8.7%), rhinorrhea (8.2%), and hemoptysis (3.3%). In subgroup analyses by continent, it was found that four symptoms have a slight prevalence variation-fever, coughing, fatigue, and diarrhea.

Conclusion: This meta-analysis found the most prevalent symptoms of COVID-19 patients were fever, coughing, fatigue, and dyspnea. This knowledge might be beneficial for the effective treatment and control of the COVID-19 outbreak. Additional studies are required to distinguish between symptoms during and after, in patients with COVID-19.

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COVID-19患者在大流行第一年的临床特征:系统回顾和荟萃分析

背景:新型冠状病毒病(COVID-19)具有较高的感染风险，在全球范围内迅速传播。然而，关于全球临床症状的数据有限。本系统综述和荟萃分析的目的是确定COVID-19患者临床症状的患病率。方法:进行系统综述和荟萃分析。检索了PubMed、CINAHL、MEDLINE、EMBASE、PsycINFO、medRxiv和Google Scholar，检索时间为2019年12月1日至2021年1月1日。采用随机效应模型对患病率进行汇总分析。异质性检验采用i平方(I2)统计量。结果:215项研究，132,647例COVID-19患者符合纳入标准。四种最常见症状的总患病率为:发热76.2% (n = 214;95% ci 73.9-78.5);咳嗽60.4% (n = 215;95% ci 58.6-62.1);疲劳33.6% (n = 175;95% ci 31.2-36.1);呼吸困难26.2% (n = 195;95% ci 24.1-28.5)。其他患病率由高到低的症状包括咳痰(22.2%)、厌食(21.6%)、肌痛(17.5%)、发冷(15%)、喉咙痛(14.1%)、头痛(11.7%)、恶心或呕吐(8.7%)、鼻漏(8.2%)和咯血(3.3%)。在各大洲的亚组分析中，发现发热、咳嗽、疲劳和腹泻四种症状有轻微的流行变化。结论:本荟萃分析发现COVID-19患者最常见的症状是发烧、咳嗽、疲劳和呼吸困难。这些知识可能有助于有效治疗和控制COVID-19疫情。需要进一步的研究来区分COVID-19患者感染期间和感染后的症状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.