Clinical Features of COVID-19 Patients in the First Year of Pandemic: A Systematic Review and Meta-Analysis.

IF 1.9 4区医学 Q2 NURSING

Biological research for nursing Pub Date : 2022-04-01 Epub Date: 2021-12-04 DOI:10.1177/10998004211055866

Mohammed Al Maqbali, Khalid Al Badi, Mohammed Al Sinani, Norah Madkhali, Geoffrey L Dickens

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引用次数: 10

Abstract

Background: The new coronavirus disease (COVID-19) carries a high risk of infection and has spread rapidly around the world. However, there are limited data about the clinical symptoms globally. The purpose of this systematic review and meta-analysis is to identify the prevalence of the clinical symptoms of patient with COVID-19.

Methods: A systematic review and meta-analysis were carried out. The following databases were searched: PubMed, CINAHL, MEDLINE, EMBASE, PsycINFO, medRxiv, and Google Scholar, from December 1st, 2019 to January 1st, 2021. Prevalence rates were pooled with meta-analysis using a random-effects model. Heterogeneity was tested using I-squared (I²) statistics.

Results: A total of 215 studies, involving 132,647 COVID-19 patients, met the inclusion criteria. The pooled prevalence of the four most common symptoms were fever 76.2% (n = 214; 95% CI 73.9-78.5); coughing 60.4% (n = 215; 95% CI 58.6-62.1); fatigue 33.6% (n = 175; 95% CI 31.2-36.1); and dyspnea 26.2% (n = 195; 95% CI 24.1-28.5). Other symptoms from highest to lowest in terms of prevalence include expectorant (22.2%), anorexia (21.6%), myalgias (17.5%), chills (15%), sore throat (14.1%), headache (11.7%), nausea or vomiting (8.7%), rhinorrhea (8.2%), and hemoptysis (3.3%). In subgroup analyses by continent, it was found that four symptoms have a slight prevalence variation-fever, coughing, fatigue, and diarrhea.

Conclusion: This meta-analysis found the most prevalent symptoms of COVID-19 patients were fever, coughing, fatigue, and dyspnea. This knowledge might be beneficial for the effective treatment and control of the COVID-19 outbreak. Additional studies are required to distinguish between symptoms during and after, in patients with COVID-19.

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COVID-19患者在大流行第一年的临床特征:系统回顾和荟萃分析

背景:新型冠状病毒病(COVID-19)具有较高的感染风险，在全球范围内迅速传播。然而，关于全球临床症状的数据有限。本系统综述和荟萃分析的目的是确定COVID-19患者临床症状的患病率。方法:进行系统综述和荟萃分析。检索了PubMed、CINAHL、MEDLINE、EMBASE、PsycINFO、medRxiv和Google Scholar，检索时间为2019年12月1日至2021年1月1日。采用随机效应模型对患病率进行汇总分析。异质性检验采用i平方(I2)统计量。结果:215项研究，132,647例COVID-19患者符合纳入标准。四种最常见症状的总患病率为:发热76.2% (n = 214;95% ci 73.9-78.5);咳嗽60.4% (n = 215;95% ci 58.6-62.1);疲劳33.6% (n = 175;95% ci 31.2-36.1);呼吸困难26.2% (n = 195;95% ci 24.1-28.5)。其他患病率由高到低的症状包括咳痰(22.2%)、厌食(21.6%)、肌痛(17.5%)、发冷(15%)、喉咙痛(14.1%)、头痛(11.7%)、恶心或呕吐(8.7%)、鼻漏(8.2%)和咯血(3.3%)。在各大洲的亚组分析中，发现发热、咳嗽、疲劳和腹泻四种症状有轻微的流行变化。结论:本荟萃分析发现COVID-19患者最常见的症状是发烧、咳嗽、疲劳和呼吸困难。这些知识可能有助于有效治疗和控制COVID-19疫情。需要进一步的研究来区分COVID-19患者感染期间和感染后的症状。

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来源期刊

Biological research for nursing 医学-护理

CiteScore

5.10

自引率

4.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)