Serum Fibroblast Growth Factor 21 Level Is Associated with Aortic Stiffness in Patients on Maintenance Hemodialysis.

IF 1.9 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Hypertension Pub Date : 2022-02-11 eCollection Date: 2022-01-01 DOI:10.1155/2022/7098458

Liang-Te Chiu, Chi-Di Hung, Lin Lin, Yu-Li Lin, Bang-Gee Hsu

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引用次数: 2

Abstract

Background: Fibroblast growth factor 21 (FGF-21) is a hormone that regulates glucose and lipid metabolism. High serum FGF-21 levels are associated with carotid atherosclerosis and coronary artery disease. This cross-sectional study aimed to assess the relationship between serum FGF-21 levels and carotid-femoral pulse wave velocity (cfPWV) in patients on maintenance hemodialysis (HD).

Methods: Blood samples and baseline characteristics were collected from 130 HD patients. Serum FGF-21 concentrations were measured with an enzyme-linked immunosorbent assay kit. Aortic stiffness was defined as a carotid-femoral pulse wave velocity (cfPWV) of more than 10 m/s.

Results: Of the 130 HD patients, aortic stiffness was diagnosed in 54 (41.5%). Serum FGF-21 levels were significantly higher in those with aortic stiffness than those without (P < 0.001). The FGF-21 level was independently associated with aortic stiffness (odds ratio (OR): 1.008; 95% CI: 1.003-1.012; P=0.001) after adjusting for diabetes mellitus, age, hypertension, C-reactive protein, and body weight in multivariable logistic regression analysis. Multivariable forward stepwise linear regression analysis also confirmed that the logarithmically transformed FGF-21 level (β = 3.245, 95% CI: 1.593-4.987, P < 0.001) was an independent predictor of cfPWV values. The area under the receiver operating characteristic (ROC) curve predicting aortic stiffness by the serum FGF-21 level was 0.693 (95% CI: 0.606-0.771, P < 0.001).

Conclusions: Serum FGF-21 level positively correlates with cfPWV and is also an independent predictor of aortic stiffness in maintenance HD patients.

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维持性血液透析患者血清成纤维细胞生长因子21水平与主动脉僵硬相关

背景:成纤维细胞生长因子21 (FGF-21)是一种调节葡萄糖和脂质代谢的激素。高血清FGF-21水平与颈动脉粥样硬化和冠状动脉疾病相关。本横断面研究旨在评估维持性血液透析(HD)患者血清FGF-21水平与颈动脉-股动脉脉波速度(cfPWV)之间的关系。方法:收集130例HD患者的血液样本及基线特征。用酶联免疫吸附测定试剂盒测定血清FGF-21浓度。主动脉僵硬定义为颈-股脉波速度(cfPWV)大于10m /s。结果:在130例HD患者中，54例(41.5%)被诊断为主动脉僵硬。主动脉僵硬组血清FGF-21水平显著高于无主动脉僵硬组(P < 0.001)。FGF-21水平与主动脉僵硬度独立相关(优势比(OR): 1.008;95% ci: 1.003-1.012;P=0.001)，在多变量logistic回归分析中校正糖尿病、年龄、高血压、c反应蛋白和体重后。多变量正向逐步线性回归分析也证实对数变换后的FGF-21水平(β = 3.245, 95% CI: 1.593-4.987, P < 0.001)是cfPWV值的独立预测因子。通过血清FGF-21水平预测主动脉硬度的受试者工作特征(ROC)曲线下面积为0.693 (95% CI: 0.606-0.771, P < 0.001)。结论:血清FGF-21水平与cfPWV呈正相关，也是维持性HD患者主动脉僵硬的独立预测因子。

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来源期刊

International Journal of Hypertension Medicine-Internal Medicine

CiteScore

4.00

自引率

5.30%

发文量

期刊介绍： International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.