Mitigation of evolved bacterial resistance to phage therapy

IF 5.7 2区医学 Q1 VIROLOGY

Current opinion in virology Pub Date : 2022-04-01 DOI:10.1016/j.coviro.2022.101201

Clara Torres-Barceló , Paul E Turner , Angus Buckling

引用次数: 19

Abstract

The ease with which bacteria can evolve resistance to phages is a key consideration for development of phage therapy. Here, we review recent work on the different evolutionary and ecological approaches to mitigate the problem. The approaches are broadly categorised into two areas: Minimising evolved phage resistance; and Directing phage-resistance evolution towards therapeutically beneficial outcomes.

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减轻进化的细菌对噬菌体治疗的耐药性

细菌进化出对噬菌体的抗性是噬菌体治疗发展的关键考虑因素。在这里，我们回顾了最近关于不同的进化和生态方法来缓解这个问题的工作。这些方法大致分为两个方面:最大限度地减少进化的噬菌体耐药性;以及引导噬菌体耐药性进化朝着治疗有益的结果发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in virology VIROLOGY-

CiteScore

11.80

自引率

5.10%

发文量

审稿时长

83 days

期刊介绍： Current Opinion in Virology (COVIRO) is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up to date with the expanding volume of information published in the field of virology. It publishes 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Emerging viruses: interspecies transmission; Viral immunology; Viral pathogenesis; Preventive and therapeutic vaccines; Antiviral strategies; Virus structure and expression; Animal models for viral diseases; Engineering for viral resistance; Viruses and cancer; Virus vector interactions. There is also a section that changes every year to reflect hot topics in the field.