An introduction to Bayes' theorem and examples of its application to a diagnostic test and a clinical trial.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-03-10 Epub Date: 2022-02-17 DOI:10.7748/nr.2022.e1816

Ha Thi Mai, Steven He, Evan Alexandrou, Steven Alfred Frost

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引用次数: 0

Abstract

Background: The Bayesian approach to updating scientific knowledge involves using a probability distribution to describe a prior belief concerning an outcome of interest and combines this with some new information to create a posterior probability distribution to describe the updated current knowledge.

Aim: To introduce the application of Bayes' theorem, using the conditional probability example of the Monty Hall problem and two examples of the clinical application of a Bayesian approach.

Discussion: Bayesian approaches enable the incorporation of prior knowledge into the interpretation of research findings and summaries of evidence to date. Bayesian approaches are being incorporated into most clinical trials.

Conclusion: Bayesian approaches to interpreting the results of a diagnostic test and a clinical trial highlight the utility of these approaches to clinical nursing and the application of evidence-based practice.

Implications for practice: Stimulation of an understanding and interest in the Bayesian approach among nurse researchers should lead to its wider application in nursing research.

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介绍贝叶斯定理及其在诊断测试和临床试验中的应用实例。

背景：更新科学知识的贝叶斯方法涉及使用概率分布来描述有关结果的先验信念，并将其与一些新信息相结合，创建后验概率分布来描述更新的当前知识。目的：使用蒙蒂-霍尔问题的条件概率例子和贝叶斯方法临床应用的两个例子，介绍贝叶斯定理的应用：贝叶斯方法能够将先验知识纳入对研究结果的解释和迄今为止的证据总结中。贝叶斯方法正被纳入大多数临床试验中：贝叶斯方法对诊断测试和临床试验结果的解释凸显了这些方法对临床护理和循证实践应用的实用性：对实践的启示：激发护士研究人员对贝叶斯方法的理解和兴趣，应能使其在护理研究中得到更广泛的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.