Evaluation of Wound Healing Activity of Sea Cucumber Holothuria parva Hydroalcoholic Extract in Rat.

IF 1.5 4区医学 Q3 DERMATOLOGY

International Journal of Lower Extremity Wounds Pub Date : 2024-09-01 Epub Date: 2021-11-18 DOI:10.1177/15347346211059331

Elnaz Bazmakdar, Eskandar Moghimipour, Neda Sistani Karampour, Annahita Rezaie, Seyed Mohammad Bagher Nabavi

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Abstract

A significant challenge in biomedicine is the development of Biomaterials with the potential to accelerate wound healing. The aim of this study was to investigate the effect of the gel prepared from sea cucumber on wound healing in rats. Full-thickness wounds were created in male rats divided into five experimental groups, negative control (NC), positive control (PC), and treatments. The NC and PC groups received respectively gel base and phenytoin cream 1%. Treatment groups were treated topically by gels of 1%, 3%, and 5% Holothuria parva extract (HPE) in the gel base. The rats were sacrificed on days 7, 14, and 21. Pathological reports revealed the proliferation of keratinocytes in the borders of the wound in treatment groups and controls. Formation of granulation tissue was seen on day 7 in treatment groups, collagen fibers in granulation tissue were randomly organized, and the rate of fibroblast decreased. Results showed that there were statistically significant differences in wound contraction between all groups in comparison to the NC group (P < .05) on day 8. It was concluded that the 1% HPE gel has a good potential for promoting wound healing.

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海参水醇提取物对大鼠伤口愈合活性的评估

生物医学面临的一个重大挑战是开发具有加速伤口愈合潜力的生物材料。本研究旨在探讨海参凝胶对大鼠伤口愈合的影响。雄性大鼠全厚伤口分为五个实验组，分别是阴性对照组（NC）、阳性对照组（PC）和治疗组。阴性对照组和阳性对照组分别使用凝胶基质和 1%苯妥英乳膏。治疗组在凝胶基质中加入 1%、3% 和 5%的 Holothuria parva 提取物（HPE）凝胶进行局部治疗。大鼠在第 7、14 和 21 天被处死。病理报告显示，治疗组和对照组的伤口边缘有角质细胞增殖。治疗组在第 7 天可见肉芽组织形成，肉芽组织中的胶原纤维呈随机组织，成纤维细胞比率下降。结果表明，与 NC 组相比，各组的伤口收缩有显著的统计学差异（P

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来源期刊

International Journal of Lower Extremity Wounds DERMATOLOGY-SURGERY

CiteScore

4.60

自引率

17.60%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Lower Extremity Wounds (IJLEW) is a quarterly, peer-reviewed journal publishing original research, reviews of evidence-based diagnostic techniques and methods, disease and patient management, and surgical and medical therapeutics for lower extremity wounds such as burns, stomas, ulcers, fistulas, and traumatic wounds. IJLEW also offers evaluations of assessment and monitoring tools, dressings, gels, cleansers, pressure management, footwear/orthotics, casting, and bioengineered skin. This journal is a member of the Committee on Publication Ethics (COPE).