Serum exosomal miR-451a acts as a candidate marker for pancreatic cancer.

IF 2.3 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

International Journal of Biological Markers Pub Date : 2022-03-01 Epub Date: 2022-01-10 DOI:10.1177/17246008211070018

Jia Chen, Dongting Yao, Weiqin Chen, Zhen Li, Yuanyuan Guo, Fan Zhu, Xiaobo Hu

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引用次数: 14

Abstract

Objectives: The aim of this study was to explore the diagnostic efficiency of serum exosomal miR-451a as a novel biomarker for pancreatic cancer.

Methods: Serum samples were collected prior to treatment. First, we analyzed microRNA (miRNA) profiles in serum exosomes from eight pancreatic cancer patients and eight healthy volunteers. We then validated the usefulness of the selected exosomal miRNAs as biomarkers in another 191 pancreatic cancer patients, 95 pancreatic benign disease (PB) patients, and 90 healthy controls.

Results: The expression of miR-451a in serum-derived exosomes from pancreatic cancer patients was significantly upregulated compared with those from PB patients and healthy individuals. Serum exosomal miR-451a showed excellent diagnostic power in identifying pancreatic cancer patients. In addition, exosomal miR-451a showed a significant association with clinical stage and distant metastasis in pancreatic cancer, and the expression level of serum exosomal miR-451a was sensitive to therapy and relapse.

Conclusions: Serum exosomal miR-451a might serve as a novel diagnostic marker for pancreatic cancer.

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血清外泌体miR-451a作为胰腺癌的候选标志物。

目的:本研究的目的是探讨血清外泌体miR-451a作为胰腺癌的新型生物标志物的诊断效率。方法:治疗前采集血清标本。首先，我们分析了8名胰腺癌患者和8名健康志愿者血清外泌体中的microRNA (miRNA)谱。然后，我们在另外191名胰腺癌患者、95名胰腺良性疾病(PB)患者和90名健康对照中验证了所选外泌体mirna作为生物标志物的有效性。结果:胰腺癌患者血清源性外泌体中miR-451a的表达与PB患者和健康个体相比显著上调。血清外泌体miR-451a在识别胰腺癌患者中显示出良好的诊断能力。此外，外泌体miR-451a与胰腺癌的临床分期和远处转移有显著相关性，血清外泌体miR-451a的表达水平对治疗和复发敏感。结论:血清外泌体miR-451a可能作为胰腺癌的一种新的诊断标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Biological Markers 医学-生物工程与应用微生物

CiteScore

4.10

自引率

0.00%

发文量

期刊介绍： IJBM is an international, online only, peer-reviewed Journal, which publishes original research and critical reviews primarily focused on cancer biomarkers. IJBM targets advanced topics regarding the application of biomarkers in oncology and is dedicated to solid tumors in adult subjects. The clinical scenarios of interests are screening and early diagnosis of cancer, prognostic assessment, prediction of the response to and monitoring of treatment.