New Reference Values for Thyroid Volume and a Comprehensive Assessment for Influencing Factors in Chinese Adults with Iodine Sufficiency.

IF 3.5 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

European Thyroid Journal Pub Date : 2021-11-01 Epub Date: 2021-07-22 DOI:10.1159/000513494

Wenxing Guo, Long Tan, Shuyao Dong, Ya Jin, Mei Zhu, Hongyan Wei, Yanting Chen, Lili Fan, Cong Du, Wanqi Zhang

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引用次数: 6

Abstract

Objectives: The reference values for thyroid volume (Tvol) determined by ultrasound require supportive data of normal Tvol from local iodine-sufficient populations. This study aimed to explore new reference values for Tvol in Chinese adults and comprehensively evaluate the factors associated with enlarged Tvol.

Methods: A cross-sectional study was conducted in Tianjin, China. Tvol was measured by ultrasound in adults with long-term iodine sufficiency. Blood and urine samples were collected to evaluate biochemical indexes, thyroid function, and iodine status.

Results: A total of 1,991 adults from the urban and suburban areas were analysed. The trend of Tvol increasing with age was observed in men under age 40 years and in women under age 52 years. In the quantile regression analyses, we found that body surface area (BSA) (β = 7.22, 95% CI: 5.33, 9.12), thyroid-stimulating hormone (TSH) (β = -1.48, 95% CI: -2.39, -0.57), thyroid nodules (TNs) (β = 6.70, 95% CI: 2.19, 11.22), and metabolic syndrome (MetS) (β = 1.40, 95% CI: 0.63, 2.17) had a strong effect on Tvol at higher percentiles in males. The dominant factors influencing Tvol were BSA (β = 9.64, 95% CI: 2.66, 16.61), TSH (β = -0.78, 95% CI: -1.16, -0.39), and TNs (β = 1.11, 95% CI: 0.43, 1.79) in females. The largest reference values for Tvol based on BSA were 20.18 (17.79, 24.32) mL in males and 15.31 (14.05, 16.70) mL in females.

Conclusions: Quantile regression analyses showed that a high BSA index, a decreased TSH level, and the prevalence of TNs were essential factors associated with the enlargement of the thyroid gland. Our findings reported the new reference values for Tvol determined by ultrasound based on gender and BSA in Chinese adults.

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中国成人甲状腺容量新参考值及碘充足影响因素综合评价。

目的:超声测定甲状腺容积(Tvol)的参考值需要当地足碘人群正常Tvol的支持数据。本研究旨在探讨中国成人Tvol的新参考值，并综合评价与Tvol增大相关的因素。方法:在中国天津进行横断面研究。用超声测量长期碘充足的成人Tvol。采集血液和尿液样本，评估生化指标、甲状腺功能和碘状态。结果:对1991名来自城市和郊区的成年人进行了分析。40岁以下男性和52岁以下女性Tvol随年龄增长呈上升趋势。在分位数回归分析中，我们发现体表面积(BSA) (β = 7.22, 95% CI: 5.33, 9.12)、促甲状腺激素(TSH) (β = -1.48, 95% CI: -2.39， -0.57)、甲状腺结节(TNs) (β = 6.70, 95% CI: 2.19, 11.22)和代谢综合征(MetS) (β = 1.40, 95% CI: 0.63, 2.17)对男性Tvol有较大的影响。影响Tvol的主要因素为女性BSA (β = 9.64, 95% CI: 2.66, 16.61)、TSH (β = -0.78, 95% CI: -1.16， -0.39)和TNs (β = 1.11, 95% CI: 0.43, 1.79)。基于BSA的Tvol最大参考值男性为20.18 (17.79,24.32)mL，女性为15.31 (14.05,16.70)mL。结论:分位数回归分析显示，高BSA指数、低TSH水平和TNs患病率是甲状腺肿大的重要因素。我们的研究结果报道了中国成人基于性别和BSA的超声测定Tvol的新参考值。

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来源期刊

European Thyroid Journal Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.70

自引率

2.10%

发文量

156

期刊介绍： The ''European Thyroid Journal'' publishes papers reporting original research in basic, translational and clinical thyroidology. Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid cancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.