Nanoparticles-stacked superhydrophilic coating supported synergistic antimicrobial ability for enhanced wound healing

IF 8.1 1区 工程技术 Q1 MATERIALS SCIENCE, BIOMATERIALS
Linhua Li , Yanan Wang , Kunpeng Liu , Li Yang , Bo Zhang , Qingfeng Luo , Rifang Luo , Yunbing Wang
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引用次数: 10

Abstract

Medical device infections have now become the major burden of healthcare, and particular administration of combating bacterial infections is of significance. In this work, robust nanoparticles-stacked superhydrophilic coatings were established through the rapid oxidation, cross-linking and aggregation of dopamine in the presence of sodium periodate. The robust superhydrophilicity was achieved and maintained due to the hydrophilic chemical components together with the micro/nano topological structure stacked by nanoparticles, resulting in an impressive nonfouling performance for proteins adsorption. Moreover, due to the presence of aromatic catechol moieties, antibiotics (e.g. norfloxacin and cephalexin) were deposited into the superhydrophilic coating in situ, by π-π stacking/hydrophobic interactions, endowing the surface with antibacterial ability. Interestingly, the superhydrophilic coatings showed a safe and effective antibacterial ability in a low dose-dependent manner because of the nonfouling platform supported killing and releasing of bacteria. The in vivo cutaneous wound healing evaluation in rats further demonstrated the synchronous effect of anti-infection and promoting wound healing. Such superhydrophilicity supported nonfouling platform was believed to open a new window to modify biomedical devices combined with wound healing and antibacterial properties.

Abstract Image

纳米颗粒堆叠的超亲水性涂层支持协同抗菌能力,增强伤口愈合
医疗器械感染已成为医疗保健的主要负担,防治细菌感染的专项管理具有重要意义。在这项工作中,通过多巴胺在高碘酸钠存在下的快速氧化、交联和聚集,建立了坚固的纳米颗粒堆叠超亲水性涂层。由于亲水性化学成分以及纳米颗粒堆叠的微纳米拓扑结构,实现并保持了强大的超亲水性,从而获得了令人印象深刻的蛋白质吸附不污染性能。此外,由于芳香族儿茶酚基团的存在,抗生素(如诺氟沙星和头孢氨苄)通过π-π堆叠/疏水相互作用在超亲水性涂层中原位沉积,赋予表面抗菌能力。有趣的是,超亲水性涂层在低剂量依赖性的情况下显示出安全有效的抗菌能力,因为无污染的平台支持杀死和释放细菌。大鼠体内皮肤创面愈合评价进一步证实了其抗感染和促进创面愈合的同步作用。这种超亲水性支持的无污垢平台被认为为修饰具有伤口愈合和抗菌性能的生物医学设备打开了新的窗口。
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来源期刊
CiteScore
12.60
自引率
0.00%
发文量
28
审稿时长
3.3 months
期刊介绍: Materials Today is a community committed to fostering the creation and sharing of knowledge and experience in materials science. With the support of Elsevier, this community publishes high-impact peer-reviewed journals, organizes academic conferences, and conducts educational webinars, among other initiatives. It serves as a hub for advancing materials science and facilitating collaboration within the scientific community.
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