The role of the IGF system in mammary physiology of ruminants

IF 1.9 2区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Wendie S. Cohick
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引用次数: 1

Abstract

The IGF system plays a central role in all stages of mammary development, lactation and involution. IGFs exert their effects on the mammary gland through both endocrine and paracrine/autocrine mechanisms and the importance of circulating versus local IGF action remains an open question, especially in ruminants. At the whole organ level, a critical role for IGFs in ductal morphogenesis and lobuloalveolar development has been established, while at the cellular level the ability of IGFs to stimulate cell proliferation and control cell survival contributes to the number of milk-secreting cells in the gland. Much of this work has been conducted in rodents which provide an affordable research model and allow for genetic manipulation of specific components of the IGF system. Research into the role of the IGF system in dairy cows has generally supported information obtained with rodents though large gaps in our knowledge remain and species differences are not well defined. Examples include whether exogenous somatotropin exerts its effects on the mammary gland through local IGF-1 synthesis which is accepted dogma in rodents, what the role of IGF-1 versus IGF-2 is in the mammary gland, and how the IGFBPs regulate IGF bioactivity. This last area is particularly under-investigated in ruminants both at the whole animal and the cellular and molecular levels. Given that the IGF system may underlie many management practices that could contribute to enhancing productive efficiency of lactation, more research into the basic biology of this important system is warranted.

IGF系统在反刍动物乳腺生理中的作用
IGF系统在乳腺发育、泌乳和复发的所有阶段起着核心作用。IGF通过内分泌和旁分泌/自分泌机制对乳腺发挥作用,循环与局部IGF作用的重要性仍然是一个悬而未决的问题,特别是在反刍动物中。在整个器官水平上,IGFs在导管形态发生和小叶肺泡发育中起着关键作用,而在细胞水平上,IGFs刺激细胞增殖和控制细胞存活的能力有助于腺体中泌乳细胞的数量。这项工作的大部分是在啮齿动物中进行的,这提供了一种负担得起的研究模式,并允许对IGF系统的特定成分进行遗传操作。对IGF系统在奶牛中的作用的研究通常支持从啮齿动物中获得的信息,尽管我们的知识仍然存在很大差距,物种差异也没有很好地定义。例如,外源性生长激素是否通过局部IGF-1合成对乳腺产生影响,这在啮齿动物中是公认的,IGF-1与IGF-2在乳腺中的作用是什么,以及igfbp如何调节IGF的生物活性。反刍动物在整个动物和细胞和分子水平上对最后一个领域的研究尤其不足。鉴于IGF系统可能是许多有助于提高泌乳生产效率的管理实践的基础,因此有必要对这一重要系统的基础生物学进行更多研究。
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来源期刊
Domestic animal endocrinology
Domestic animal endocrinology 农林科学-奶制品与动物科学
CiteScore
5.50
自引率
4.80%
发文量
58
审稿时长
31 days
期刊介绍: Domestic Animal Endocrinology publishes scientific papers dealing with the study of the endocrine physiology of domestic animal species. Those manuscripts utilizing other species as models for clinical or production problems associated with domestic animals are also welcome. Topics covered include: Classical and reproductive endocrinology- Clinical and applied endocrinology- Regulation of hormone secretion- Hormone action- Molecular biology- Cytokines- Growth factors
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