Parvovirus B19 Infection Is Associated with Autoimmune Thyroid Disease in Adults.

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology and Metabolism Pub Date : 2021-09-20 eCollection Date: 2021-10-01 DOI:10.5812/ijem.115592

Zahra Heidari, Maede Jami

{"title":"Parvovirus B19 Infection Is Associated with Autoimmune Thyroid Disease in Adults.","authors":"Zahra Heidari, Maede Jami","doi":"10.5812/ijem.115592","DOIUrl":null,"url":null,"abstract":"Background: Autoimmune thyroid diseases are the most frequent autoimmune disorders, with a global prevalence of about 10%. Several mechanisms have been proposed to induce autoimmune thyroid responses by infectious agents. In this study, we aimed to evaluate the association between parvovirus B19 infection and autoimmune thyroid disorders.Methods: Adult patients with newly diagnosed Graves' disease (GD) and Hashimoto's thyroiditis (HT) and healthy euthyroid controls were recruited. Various clinical and biochemical parameters, including thyroid function tests and serum parvovirus B19 antibody level (IgG), were assessed and compared between the groups.Results: In this study, data from 404 cases with HT, 248 cases with GD, and 480 healthy individuals as a control group were analyzed. The prevalence of parvovirus B19 infection in patients with HT and GD and controls was 61.1%, 58.9%, and 47.1%, respectively. In the group of patients with HT, there was a significant positive correlation between the B19 IgG and TPOAb (r = 0.764, P < 0.001) and TgAb (r = 0.533, P < 0.001). Also, in patients with GD, the B19 IgG had a significant positive correlation with TPOAb (r = 0.779, P < 0.001) and TgAb (r = 0.467, P < 0.001).Conclusions: Parvovirus B19 infection is commonly seen in patients with autoimmune thyroid disorders.","PeriodicalId":13969,"journal":{"name":"International Journal of Endocrinology and Metabolism","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/e2/ijem-19-4-115592.PMC8762377.pdf","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Endocrinology and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5812/ijem.115592","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/10/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 5

Abstract

Background: Autoimmune thyroid diseases are the most frequent autoimmune disorders, with a global prevalence of about 10%. Several mechanisms have been proposed to induce autoimmune thyroid responses by infectious agents. In this study, we aimed to evaluate the association between parvovirus B19 infection and autoimmune thyroid disorders.

Methods: Adult patients with newly diagnosed Graves' disease (GD) and Hashimoto's thyroiditis (HT) and healthy euthyroid controls were recruited. Various clinical and biochemical parameters, including thyroid function tests and serum parvovirus B19 antibody level (IgG), were assessed and compared between the groups.

Results: In this study, data from 404 cases with HT, 248 cases with GD, and 480 healthy individuals as a control group were analyzed. The prevalence of parvovirus B19 infection in patients with HT and GD and controls was 61.1%, 58.9%, and 47.1%, respectively. In the group of patients with HT, there was a significant positive correlation between the B19 IgG and TPOAb (r = 0.764, P < 0.001) and TgAb (r = 0.533, P < 0.001). Also, in patients with GD, the B19 IgG had a significant positive correlation with TPOAb (r = 0.779, P < 0.001) and TgAb (r = 0.467, P < 0.001).

Conclusions: Parvovirus B19 infection is commonly seen in patients with autoimmune thyroid disorders.

Abstract Image

查看原文本刊更多论文

成人细小病毒B19感染与自身免疫性甲状腺疾病相关

背景:自身免疫性甲状腺疾病是最常见的自身免疫性疾病，全球患病率约为10%。几种机制已被提出，以诱导自身免疫性甲状腺反应的感染性病原体。在这项研究中，我们旨在评估细小病毒B19感染与自身免疫性甲状腺疾病之间的关系。方法:招募新诊断为Graves病(GD)和桥本甲状腺炎(HT)的成年患者和健康的甲状腺正常对照。比较两组患者甲状腺功能、血清细小病毒B19抗体(IgG)水平等临床生化指标。结果:本研究分析了404例HT、248例GD和480例健康个体作为对照组的数据。HT、GD患者和对照组中细小病毒B19感染率分别为61.1%、58.9%和47.1%。在HT组中，B19 IgG与TPOAb (r = 0.764, P < 0.001)、TgAb (r = 0.533, P < 0.001)呈显著正相关。GD患者B19 IgG与TPOAb (r = 0.779, P < 0.001)、TgAb (r = 0.467, P < 0.001)呈显著正相关。结论:细小病毒B19感染常见于自身免疫性甲状腺疾病患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.