Biomarkers involved in the proliferation of the odontogenic keratocyst, glandular odontogenic cyst and botryoid odontogenic cyst.

Oral and maxillofacial surgery Pub Date : 2022-12-01 Epub Date: 2022-01-21 DOI:10.1007/s10006-021-01026-x

Joaquim Felipe Júnior, Glória Maria de França, Caio César da Silva Barros, Fernanda Aragão Felix, Weslay Rodrigues da Silva, Hévio Freitas de Lucena, Cláudia Nunes Oliveira, Hébel Cavalcanti Galvão

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引用次数: 5

Abstract

Introduction: Odontogenic cysts are a heterogeneous group of lesions with varied clinical behavior.

Objective: To analyze the expression of the epidermal growth factor receptor (EGFR), Cyclin D1, and transcription factor SOX2 in the odontogenic epithelium evaluating the cell cycle control and cystic expansion.

Methods: This was a cross-sectional study including 40 cases, 20 odontogenic keratocysts (OKC), 10 botryoid odontogenic cysts (BOC), and 10 glandular odontogenic cysts (GOC).

Results: All cases of OKC, BOC, and GOC were positive for EGFR in all layers of the cyst lining. The highest expression of nuclear Cyclin D1 was observed in the suprabasal layer of OKCs and in the basal and suprabasal layers of GOC and BOC (p < 0.001). In addition, SOX2 was only expressed in the suprabasal layer of OKCs.

Conclusion: The high expression of EGFR in the cyst membrane suggests that EGF stimulates epithelial proliferation in BOCs, and the high expression of SOX2 in OKCs may be related to the presence of stem cells in the lesion. Cyclin D1 is related to cell cycle disruption in G1-S contributing to stimulates epithelial proliferation of OKCs and GOCs and BOCs.

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参与牙源性角化囊肿、腺性牙源性囊肿和骨样牙源性囊肿增生的生物标志物。

牙源性囊肿是一种具有不同临床表现的异质性病变。目的:分析表皮生长因子受体(EGFR)、细胞周期蛋白D1和转录因子SOX2在牙源性上皮中的表达，评价细胞周期调控和囊性扩张的作用。方法:对40例牙源性角化囊肿(OKC) 20例、骨样牙源性囊肿(BOC) 10例、腺性牙源性囊肿(GOC) 10例进行横断面研究。结果:所有OKC、BOC和GOC患者在囊肿内膜各层均呈EGFR阳性。核Cyclin D1在OKCs的基上层、GOC和BOC的基上层和基上层表达最高(p < 0.001)。此外，SOX2仅在OKCs的基上层表达。结论:囊肿膜中EGFR的高表达提示EGF刺激BOCs中上皮细胞的增殖，OKCs中SOX2的高表达可能与病变中干细胞的存在有关。Cyclin D1与G1-S的细胞周期中断有关，有助于刺激OKCs、GOCs和BOCs的上皮增殖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Oral and maxillofacial surgery

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