An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL

Bioactive Materials Pub Date : 2022-04-01 DOI:10.1016/j.bioactmat.2021.08.019

Jiacheng Guo , Zhenzhen Yang , Yongzheng Lu , Chunyan Du , Chang Cao , Bo Wang , Xiaoting Yue , Zenglei Zhang , Yanyan Xu , Zhen Qin , Tingting Huang , Wei Wang , Wei Jiang , Jinying Zhang , Junnan Tang

{"title":"An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair","authors":"Jiacheng Guo , Zhenzhen Yang , Yongzheng Lu , Chunyan Du , Chang Cao , Bo Wang , Xiaoting Yue , Zenglei Zhang , Yanyan Xu , Zhen Qin , Tingting Huang , Wei Wang , Wei Jiang , Jinying Zhang , Junnan Tang","doi":"10.1016/j.bioactmat.2021.08.019","DOIUrl":null,"url":null,"abstract":"<div><p>Acute myocardial infarction (AMI) remains a dominant origin of morbidity, mortality and disability worldwide. Increases in reactive oxygen species (ROS) are key contributor to excessive cardiac injury after AMI. Here we developed an immobilized enzyme with Superoxide Dismutase (SOD) activity cross-link with Zr-based metal-organic framework (ZrMOF) (SOD-ZrMOF) for mitigate ROS-caused injury. <em>In vitro</em> and <em>in vivo</em> evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility. By efficiently scavenging ROS and suppressing oxidative stress, SOD-ZrMOF can protect the function of mitochondria, reduce cell death and alleviate inflammation. More excitingly, long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area, protect cardiac function, promote angiogenesis and inhibit pathological myocardial remodeling. Therefore, SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI.</p></div>","PeriodicalId":8762,"journal":{"name":"Bioactive Materials","volume":"10 ","pages":"Pages 56-67"},"PeriodicalIF":18.0000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bioactmat.2021.08.019","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioactive Materials","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452199X21003959","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}

引用次数: 6

Abstract

Acute myocardial infarction (AMI) remains a dominant origin of morbidity, mortality and disability worldwide. Increases in reactive oxygen species (ROS) are key contributor to excessive cardiac injury after AMI. Here we developed an immobilized enzyme with Superoxide Dismutase (SOD) activity cross-link with Zr-based metal-organic framework (ZrMOF) (SOD-ZrMOF) for mitigate ROS-caused injury. In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility. By efficiently scavenging ROS and suppressing oxidative stress, SOD-ZrMOF can protect the function of mitochondria, reduce cell death and alleviate inflammation. More excitingly, long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area, protect cardiac function, promote angiogenesis and inhibit pathological myocardial remodeling. Therefore, SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI.

Abstract Image

查看原文本刊更多论文

一种将超氧化物歧化酶偶联到金属-有机骨架上用于心脏修复的抗氧化系统

急性心肌梗死(AMI)仍然是世界范围内发病率、死亡率和致残率的主要来源。活性氧(ROS)的增加是AMI后过度心脏损伤的关键因素。本研究开发了一种具有超氧化物歧化酶(SOD)活性的固定化酶，该酶与锆基金属有机骨架(ZrMOF) (SOD-ZrMOF)交联，可减轻ros引起的损伤。体外和体内实验表明，SOD-ZrMOF具有良好的生物相容性。SOD-ZrMOF通过有效清除ROS，抑制氧化应激，保护线粒体功能，减少细胞死亡，减轻炎症。更令人兴奋的是，通过AMI动物模型的长期研究表明，SOD-ZrMOF可以减少梗死面积，保护心功能，促进血管生成，抑制病理性心肌重构。因此，SOD-ZrMOF作为一种有效、安全的AMI纳米材料治疗具有很大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.