Feasibility of Magnetic Technique for Axillary Staging after Neoadjuvant Therapy in Breast Cancer Patients.

IF 2.1 4区 医学 Q2 SURGERY
Journal of Investigative Surgery Pub Date : 2022-06-01 Epub Date: 2022-02-17 DOI:10.1080/08941939.2022.2038737
Osman Cem Yılmaz, Veli Vural
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引用次数: 1

Abstract

Purpose: Optimal axillary staging after neoadjuvant chemotherapy (NAC) in node-negative breast cancer is an area of controversy. Sentinel node biopsy with Technetium-sulphur colloid (99m Tc) alone or with blue dye is the recommended technique for evaluating axilla in these patients. However, this technique has drawbacks such as limited access to nuclear departments and timing limitations related to Tc injection exposing patients to unnecessary radiation. Superparamagnetic iron oxide nanoparticles (SPIO) may represent a valid option for SLN biopsy. In this study, we assessed the feasibility of the magnetic technique (Sentimag) with combination of isosulfan blue dye in breast cancer patients who received NAC.

Methods: The study sample consisted of 54 female breast cancer patients who received NAC. Sentinel node localization was performed using magnetic technique and blue dye. Sentinel node identification rate (IFR) of magnetic technique was calculated and postoperative complications were assessed.

Results: Sentinel lymph node was detected in 52 patients with Sentimag method (identification rate = 96.3%, 95% CI: 87.4-98.9%). Blue dye was successful to find SLN in 38 patients (identification rate = 70%). The most common histologic type was invasive ductal (n = 51; 94.4%). Mean tumor size was 2.1 cm after NAC. Most of patients had T2 (n = 30; 55.5%) and HER2 + positive (n = 49; 90.7%) cancer.

Conclusion: Sentimag which is a magnetic technique appears to be safe, easy to perform with minimal adverse effects, may be an alternative and accurate technique in patients with NAC, especially in breast units where nuclear medicine unit is not available.

Supplemental data for this article is available online at https://doi.org/10.1080/08941939.2022.2038737 .

磁共振技术在乳腺癌患者新辅助治疗后腋窝分期中的可行性。
目的:淋巴结阴性乳腺癌新辅助化疗(NAC)后最佳腋窝分期是一个有争议的领域。前哨淋巴结活检单独使用锝硫胶体(99m Tc)或蓝色染料是评估这些患者腋窝的推荐技术。然而,这种技术有一些缺点,比如进入核科的机会有限,以及注射Tc使患者暴露在不必要的辐射下的时间限制。超顺磁性氧化铁纳米颗粒(SPIO)可能是SLN活检的有效选择。在这项研究中,我们评估了磁性技术(Sentimag)联合异硫丹蓝染料在接受NAC的乳腺癌患者中的可行性。方法:研究对象为54例接受NAC治疗的女性乳腺癌患者。前哨淋巴结定位采用磁性技术和蓝色染料。计算磁导术前哨淋巴结识别率(IFR),并评估术后并发症。结果:52例患者采用Sentimag方法检出前哨淋巴结,检出率为96.3%,95% CI: 87.4 ~ 98.9%。蓝色染色成功发现SLN 38例(检出率70%)。最常见的组织学类型为浸润性导管性(n = 51;94.4%)。NAC术后平均肿瘤大小为2.1 cm。大多数患者有T2 (n = 30;55.5%)和HER2 +阳性(n = 49;90.7%)癌症。结论:Sentimag是一种安全、操作简单、不良反应小的磁性技术,可作为NAC患者的替代技术,特别是在没有核医学单元的乳腺科室。本文的补充数据可在https://doi.org/10.1080/08941939.2022.2038737上在线获得。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
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