Mechanical properties, in vitro and in vivo biocompatibility analysis of pure iron porous implant produced by metal injection molding: A new eco-friendly feedstock from natural rubber (Hevea brasiliensis)

IF 8.1 1区 工程技术 Q1 MATERIALS SCIENCE, BIOMATERIALS
Diego Pacheco Wermuth , Thaís Casagrande Paim , Isadora Bertaco , Carla Zanatelli , Liliana Ivet Sous Naasani , Mônica Slaviero , David Driemeier , André Carvalho Tavares , Vinicius Martins , Camila Ferreira Escobar , Luis Alberto Loureiro dos Santos , Lirio Schaeffer , Márcia Rosângela Wink
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引用次数: 9

Abstract

Metal injection molding (MIM) has become an important manufacturing technology for biodegradable medical devices. As a biodegradable metal, pure iron is a promising biomaterial due to its mechanical properties and biocompatibility. In light of this, we performed the first study that manufactured and evaluated the in vitro and in vivo biocompatibility of samples of iron porous implants produced by MIM with a new eco-friendly feedstock from natural rubber (Hevea brasiliensis), a promisor binder that provides elastic property in the green parts. The iron samples were submitted to tests to determine density, microhardness, hardness, yield strength, and stretching. The biocompatibility of the samples was studied in vitro with adipose-derived mesenchymal stromal cells (ADSCs) and erythrocytes, and in vivo on a preclinical model with Wistar rats, testing the iron samples after subcutaneous implant. Results showed that the manufactured samples have adequate physical, and mechanical characteristics to biomedical devices and they are cytocompatible with ADSCs, hemocompatible and biocompatible with Wistars rats. Therefore, pure iron produced by MIM can be considered a promising material for biomedical applications.

Abstract Image

金属注射成型纯铁多孔植入物的力学性能、体外和体内生物相容性分析——天然橡胶(巴西橡胶树)的新型环保原料
金属注射成型(MIM)已成为生物可降解医疗器械的重要制造技术。纯铁作为一种生物可降解的金属,由于其良好的力学性能和生物相容性,是一种很有前途的生物材料。鉴于此,我们进行了第一项研究,制造并评估了MIM生产的铁多孔植入物样品的体外和体内生物相容性,该植入物采用了一种新的环保原料,即天然橡胶(巴西橡胶树),一种在绿色部分提供弹性特性的混合粘合剂。铁样品提交测试,以确定密度,显微硬度,硬度,屈服强度和拉伸。体外与脂肪源性间充质间质细胞(ADSCs)和红细胞进行生物相容性研究,并在体内与Wistar大鼠建立临床前模型,测试铁样品皮下植入后的生物相容性。结果表明,制备的样品具有足够的生物医学器件物理和力学特性,与ADSCs具有细胞相容性,与Wistars大鼠具有血液相容性和生物相容性。因此,由MIM制备的纯铁可以被认为是一种有前景的生物医学应用材料。
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来源期刊
CiteScore
12.60
自引率
0.00%
发文量
28
审稿时长
3.3 months
期刊介绍: Materials Today is a community committed to fostering the creation and sharing of knowledge and experience in materials science. With the support of Elsevier, this community publishes high-impact peer-reviewed journals, organizes academic conferences, and conducts educational webinars, among other initiatives. It serves as a hub for advancing materials science and facilitating collaboration within the scientific community.
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