On-demand pulling-off of magnetic nanoparticles from biomaterial surfaces through implant-associated infectious biofilms for enhanced antibiotic efficacy

IF 8.1 1区 工程技术 Q1 MATERIALS SCIENCE, BIOMATERIALS
Kecheng Quan , Zexin Zhang , Yijin Ren , Henk J. Busscher , Henny C. van der Mei , Brandon W. Peterson
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引用次数: 2

Abstract

Biomaterial-associated infections can occur any time after surgical implantation of biomaterial implants and limit their success rates. On-demand, antimicrobial release coatings have been designed, but in vivo release triggers uniquely relating with infection do not exist, while inadvertent leakage of antimicrobials can cause exhaustion of a coating prior to need. Here, we attach magnetic-nanoparticles to a biomaterial surface, that can be pulled-off in a magnetic field through an adhering, infectious biofilm. Magnetic-nanoparticles remained stably attached to a surface upon exposure to PBS for at least 50 days, did not promote bacterial adhesion or negatively affect interaction with adhering tissue cells. Nanoparticles could be magnetically pulled-off from a surface through an adhering biofilm, creating artificial water channels in the biofilm. At a magnetic-nanoparticle coating concentration of 0.64 mg cm−2, these by-pass channels increased the penetrability of Staphylococcus aureus and Pseudomonas aeruginosa biofilms towards different antibiotics, yielding 10-fold more antibiotic killing of biofilm inhabitants than in absence of artificial channels. This innovative use of magnetic-nanoparticles for the eradication of biomaterial-associated infections requires no precise targeting of magnetic-nanoparticles and allows more effective use of existing antibiotics by breaking the penetration barrier of an infectious biofilm adhering to a biomaterial implant surface on-demand.

Abstract Image

磁性纳米颗粒通过植入物相关的感染性生物膜从生物材料表面按需剥离,以增强抗生素疗效
生物材料相关感染可发生在生物材料植入手术后的任何时间,并限制其成功率。按需抗菌药物释放涂层已经被设计出来,但是与感染相关的体内释放触发器并不存在,而无意的抗菌药物泄漏可能导致涂层在需要之前耗尽。在这里,我们将磁性纳米颗粒附着在生物材料表面,可以在磁场中通过粘附的、具有传染性的生物膜将其剥离。磁性纳米颗粒在暴露于PBS至少50天后仍然稳定地附着在表面,不会促进细菌粘附或对粘附组织细胞的相互作用产生负面影响。纳米粒子可以通过附着的生物膜被磁性地从表面拉下来,在生物膜中形成人工水通道。当磁性纳米颗粒涂层浓度为0.64 mg cm - 2时,这些旁路通道增加了金黄色葡萄球菌和铜绿假单胞菌生物膜对不同抗生素的渗透性,与没有人工通道时相比,对生物膜居民的抗生素杀伤效果提高了10倍。磁性纳米颗粒的这种创新应用,消除了与生物材料相关的感染,不需要精确靶向磁性纳米颗粒,并允许更有效地利用现有的抗生素,通过打破附着在生物材料植入物表面的感染性生物膜的渗透屏障。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.60
自引率
0.00%
发文量
28
审稿时长
3.3 months
期刊介绍: Materials Today is a community committed to fostering the creation and sharing of knowledge and experience in materials science. With the support of Elsevier, this community publishes high-impact peer-reviewed journals, organizes academic conferences, and conducts educational webinars, among other initiatives. It serves as a hub for advancing materials science and facilitating collaboration within the scientific community.
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