Patients'satisfaction and experience in treatment with opioid substitution therapy in Spain. The PREDEPO study.

IF 2.2 4区 医学 Q3 SUBSTANCE ABUSE
Francisco Pascual Pastor, Álvaro Muñoz, Rodrigo Oraa, Gerardo Flórez, Pilar Notario, Pedro Seijo, Begoña Gonzalvo, Carla Assaf, Manuel Gómez, Miguel Ángel Casado
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Abstract

The aim of this study was to compare patients' satisfaction, experience, objectives, and opinion based on their current opioid substitution therapy (OST) (buprenorphine/naloxone (B/N) or methadone). The PREDEPO study is an observational, cross-sectional, multicentric study performed in Spain. Adult patients diagnosed with opioid use disorder (OUD) receiving OST were included. They were asked to fill in a questionnaire regarding their current OST. A total of 98 patients were enrolled (B/N: 50%, methadone: 50%). Mean age was 47 ± 8 years old and 80% were male. Treatment satisfaction was similar between groups. The most frequently reported factor for being "very/quite satisfied" was "being able to distribute the dose at different times throughout the day" (44% B/N vs. 63% methadone; p = .122). A significantly lower proportion of patients in the B/N group versus the methadone group reported that having to collect the medication daily was "very/quite annoying" (19% vs. 52%, p = .032). Treatment objectives reported by the majority of patients were similar between groups ("not feeling in withdrawal anymore", "reduce/definitely stop drug use", "improve my health", and "stop thinking about using daily") except for "not having money problems anymore" (73% B/N vs. 92% methadone; p = .012).  These results suggest there are several unmet expectations regarding current OST. There is a need for new treatments that reduce the burden of OUD, avoid the need for daily dosing, and are less stigmatizing which in turn could improve patient management, adherence and, quality of life.

西班牙患者对阿片类药物替代疗法的满意度和治疗经验。PREDEPO 研究。
本研究旨在比较患者对目前阿片类药物替代疗法(OST)(丁丙诺啡/纳洛酮(B/N)或美沙酮)的满意度、体验、目标和看法。PREDEPO 研究是一项在西班牙进行的多中心横断面观察性研究。研究对象包括被诊断患有阿片类药物使用障碍 (OUD) 并接受 OST 治疗的成年患者。他们被要求填写一份有关其当前 OST 的问卷。共有 98 名患者被纳入研究(B/N:50%,美沙酮:50%)。平均年龄为 47 ± 8 岁,80% 为男性。各组的治疗满意度相似。最常报告的 "非常满意/比较满意 "的因素是 "能够在一天中的不同时间分配剂量"(44% B/N vs. 63% 美沙酮;p = .122)。在 B/N 组与美沙酮组中,报告 "非常/比较烦 "每天必须取药的患者比例明显较低(19% 对 52%,p = 0.032)。除了 "不再有金钱问题"(B/N 组 73% 对美沙酮组 92%;P = .012)之外,大多数患者所报告的治疗目标在两组之间是相似的("不再感到戒断"、"减少/绝对停止吸毒"、"改善我的健康状况 "和 "不再想每天吸毒")。 这些结果表明,目前的 OST 有几项期望没有得到满足。我们需要新的治疗方法来减轻 OUD 的负担,避免每日服药,减少耻辱感,从而改善患者的管理、依从性和生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Adicciones
Adicciones SUBSTANCE ABUSE-
CiteScore
4.00
自引率
10.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: Adicciones publica artículos originales sobre el tratamiento, la prevención, estudios básicos y descriptivos en el campo de las adicciones, como son las drogas ilegales, el alcohol, el tabaco o cualquier otra adicción, procedentes de distintas disciplinas (medicina, psicología, investigación básica, investigación social, etc.). Todos los artículos son seleccionados después de pasar un proceso de revisión anónimo hecho por expertos en ese tema.
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