Long non-coding RNAs as emerging regulators of miRNAs and epigenetics in diabetes-related chronic kidney disease.

IF 2.5 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Vishwadeep Shelke, Ajinath Kale, Himanshu Sankrityayan, Hans-Joachim Anders, Anil Bhanudas Gaikwad
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引用次数: 0

Abstract

Diabetes is one of the major cause of chronic kidney disease (CKD), including "diabetic nephropathy," and is an increasingly prevalent accelerator of the progression of non-diabetic forms of CKD. The long non-coding RNAs (lncRNAs) have come into the limelight in the past few years as one of the emerging weapons against CKD in diabetes. Available data over the past few years demonstrate the interaction of lncRNAs with miRNAs and epigenetic machinery. Interestingly, the evolving data suggest that lncRNAs play a vital role in diabetes-associated CKD by regulation of epigenetic enzymes such as DNA methyltransferase, histone deacetylases, and histone methyltransferases. LncRNAs are also engaged in the regulation of several miRNAs in diabetic nephropathy. Hence this review will elaborate on the association between lncRNAs and their interaction with epigenetic regulators involved in different aspects and thus the progression of CKD in diabetes.

长非编码 RNA 是糖尿病相关慢性肾病中 miRNA 和表观遗传学的新兴调节因子。
糖尿病是包括 "糖尿病肾病 "在内的慢性肾病(CKD)的主要病因之一,也是非糖尿病形式的慢性肾病日益普遍的加速因素。在过去几年中,长非编码 RNA(lncRNA)作为对抗糖尿病 CKD 的新兴武器之一备受关注。过去几年的现有数据表明,lncRNA 与 miRNA 和表观遗传机制之间存在相互作用。有趣的是,不断发展的数据表明,lncRNAs 通过调节 DNA 甲基转移酶、组蛋白去乙酰化酶和组蛋白甲基转移酶等表观遗传酶,在糖尿病相关性 CKD 中发挥着重要作用。在糖尿病肾病中,LncRNAs 也参与了多种 miRNAs 的调控。因此,本综述将详细阐述 lncRNA 与表观遗传调节因子之间的关联及其在不同方面的相互作用,进而影响糖尿病 CKD 的进展。
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来源期刊
Archives of Physiology and Biochemistry
Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY
CiteScore
6.90
自引率
3.30%
发文量
21
期刊介绍: Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.
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