Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis.

Microbiology insights Pub Date : 2021-11-29 eCollection Date: 2021-01-01 DOI:10.1177/11786361211053344

Canna Jagdish Ghia, Gautam Sudhakar Rambhad

{"title":"Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis.","authors":"Canna Jagdish Ghia, Gautam Sudhakar Rambhad","doi":"10.1177/11786361211053344","DOIUrl":null,"url":null,"abstract":"Objective: To perform systematic review and meta-analysis of meningococcal disease burden in India.Methods: We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar. Prevalence (proportion) of Meningococcal meningitis and Case-fatality ratio (CFR) were pooled using random effects model. Other outcomes were pooled qualitatively.Results: The prevalence of Meningococcal meningitis in epidemic and endemic conditions was 12.1% (95% CI: 5.2-21.4) and 0.76% (95% CI: 0.3-1.4), respectively, with a CFR of 12.8% (95% CI: 6.8-20.4) in epidemic settings; N. meningitis caused 3.2% (95% CI: 1.6-5.3) of Acute Bacterial Meningitis (ABM) cases in endemic settings. The disease appeared in infants, adolescents, and adults with Serogroup A prevalence. Treatment and prophylaxis were limited to antibiotics despite increased resistance.Conclusion: The study reveals epidemic and endemic presence of the disease in India with high fatality and serogroup A prevalence. Further monitoring and immunization are required to prevent outbreaks.","PeriodicalId":74187,"journal":{"name":"Microbiology insights","volume":"14 ","pages":"11786361211053344"},"PeriodicalIF":0.0000,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/e7/10.1177_11786361211053344.PMC8637695.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbiology insights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/11786361211053344","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

Abstract

Objective: To perform systematic review and meta-analysis of meningococcal disease burden in India.

Methods: We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar. Prevalence (proportion) of Meningococcal meningitis and Case-fatality ratio (CFR) were pooled using random effects model. Other outcomes were pooled qualitatively.

Results: The prevalence of Meningococcal meningitis in epidemic and endemic conditions was 12.1% (95% CI: 5.2-21.4) and 0.76% (95% CI: 0.3-1.4), respectively, with a CFR of 12.8% (95% CI: 6.8-20.4) in epidemic settings; N. meningitis caused 3.2% (95% CI: 1.6-5.3) of Acute Bacterial Meningitis (ABM) cases in endemic settings. The disease appeared in infants, adolescents, and adults with Serogroup A prevalence. Treatment and prophylaxis were limited to antibiotics despite increased resistance.

Conclusion: The study reveals epidemic and endemic presence of the disease in India with high fatality and serogroup A prevalence. Further monitoring and immunization are required to prevent outbreaks.

Abstract Image

查看原文本刊更多论文

印度脑膜炎球菌疾病负担:系统回顾和荟萃分析。

目的:对印度脑膜炎球菌疾病负担进行系统回顾和荟萃分析。方法:我们使用PubMed和Google Scholar检索1996年至2020年间印度关于脑膜炎球菌病的出版物。采用随机效应模型汇总脑膜炎球菌性脑膜炎患病率(比例)和病死率(CFR)。其他结果进行定性汇总。结果:流行性脑膜炎和地方性脑膜炎的患病率分别为12.1% (95% CI: 5.2-21.4)和0.76% (95% CI: 0.3-1.4)，在流行环境中，CFR为12.8% (95% CI: 6.8-20.4);在地方性环境中，急性细菌性脑膜炎(ABM)病例中有3.2% (95% CI: 1.6-5.3)是由N.脑膜炎引起的。该病出现在婴儿、青少年和成人血清A组患病率。尽管耐药性增加，但治疗和预防仅限于抗生素。结论:该研究揭示了该疾病在印度的流行和地方性存在，具有高致死率和血清A组患病率。需要进一步监测和免疫以预防疫情。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Microbiology insights

自引率

0.00%

发文量

审稿时长

8 weeks