Genetic variants affecting chemical mediated skin immunotoxicity.

IF 6.4 2区医学 Q1 ENVIRONMENTAL SCIENCES

Journal of Toxicology and Environmental Health-Part B-Critical Reviews Pub Date : 2022-02-17 Epub Date: 2022-01-03 DOI:10.1080/10937404.2021.2013372

Isisdoris Rodrigues de Souza, Patrícia Savio de Araujo-Souza, Daniela Morais Leme

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引用次数: 2

Abstract

The skin is an immune-competent organ and this function may be impaired by exposure to chemicals, which may ultimately result in immune-mediated dermal disorders. Interindividual variability to chemical-induced skin immune reactions is associated with intrinsic individual characteristics and their genomes. In the last 30-40 years, several genes influencing susceptibility to skin immune reactions were identified. The aim of this review is to provide information regarding common genetic variations affecting skin immunotoxicity. The polymorphisms selected for this review are related to xenobiotic-metabolizing enzymes (CYPA1 and CYPB1 genes), antioxidant defense (GSTM1, GSTT1, and GSTP1 genes), aryl hydrocarbon receptor signaling pathway (AHR and ARNT genes), skin barrier function transepidermal water loss (FLG, CASP14, and SPINK5 genes), inflammation (TNF, IL10, IL6, IL18, IL31, and TSLP genes), major histocompatibility complex (MHC) and neuroendocrine system peptides (CALCA, TRPV1, ACE genes). These genes present variants associated with skin immune responses and diseases, as well as variants associated with protecting skin immune homeostasis following chemical exposure. The molecular and association studies focusing on these genetic variants may elucidate their functional consequences and contribution in the susceptibility to skin immunotoxicity. Providing information on how genetic variations affect the skin immune system may reduce uncertainties in estimating chemical hazards/risks for human health in the future.

查看原文本刊更多论文

影响化学介导的皮肤免疫毒性的遗传变异。

皮肤是一种具有免疫功能的器官，这种功能可能因接触化学物质而受损，最终可能导致免疫介导的皮肤疾病。化学诱导的皮肤免疫反应的个体间变异与个体内在特征及其基因组有关。在过去的30-40年里，几个影响皮肤免疫反应易感性的基因被鉴定出来。本综述的目的是提供有关影响皮肤免疫毒性的常见遗传变异的信息。本综述选择的多态性与外源代谢酶(CYPA1和CYPB1基因)、抗氧化防御(GSTM1、GSTT1和GSTP1基因)、芳烃受体信号通路(AHR和ARNT基因)、皮肤屏障功能经皮失水(FLG、CASP14和SPINK5基因)、炎症(TNF、IL10、IL6、IL18、IL31和TSLP基因)、主要组织相容性复合体(MHC)和神经内分泌系统肽(CALCA、TRPV1、ACE基因)有关。这些基因存在与皮肤免疫反应和疾病相关的变异，以及与化学物质暴露后保护皮肤免疫稳态相关的变异。对这些遗传变异的分子和关联研究可能会阐明它们的功能后果和对皮肤免疫毒性易感性的贡献。提供有关遗传变异如何影响皮肤免疫系统的信息，可能会减少未来评估化学品对人类健康危害/风险的不确定性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Toxicology and Environmental Health-Part B-Critical Reviews 环境科学-毒理学

CiteScore

13.80

自引率

6.90%

发文量

审稿时长

>24 weeks

期刊介绍： "Journal of Toxicology and Environmental Health: Part B - Critical Reviews" is an academic journal published by Taylor & Francis, focusing on the critical examination of research in the areas of environmental exposure and population health. With an ISSN identifier of 1093-7404, this journal has established itself as a significant source of scholarly content in the field of toxicology and environmental health. Since its inception, the journal has published over 424 articles that have garnered 35,097 citations, reflecting its impact and relevance in the scientific community. Known for its comprehensive reviews, the journal also goes by the names "Critical Reviews" and "Journal of Toxicology & Environmental Health, Part B, Critical Reviews." The journal's mission is to provide a platform for in-depth analysis and critical discussion of the latest findings in toxicology, environmental health, and related disciplines. By doing so, it contributes to the advancement of knowledge and understanding of the complex interactions between environmental factors and human health, aiding in the development of strategies to protect and improve public health.