SARS-CoV-2 seroprevalence in high-risk health care workers in a Belgian general hospital: evolution from the first wave to the second.

IF 1.6 4区 医学 Q2 Medicine
Acta Clinica Belgica Pub Date : 2022-12-01 Epub Date: 2021-11-18 DOI:10.1080/17843286.2021.2004349
Loris Wauthier, Quentin Delefortrie, Nicolas Eppe, Patrick Vankerkhoven, Eva Wolff, Mélanie Dekeyser, Jean-Michel Cirriez, Alexandre Grimmelprez
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引用次数: 5

Abstract

Health care workers (HCWs) are at the frontline for combatting the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To describe recent or past infections, the novel development of serological assays enabled the assessment of the immune response developed in coronavirus disease (COVID-19). Here, we investigate SARS-CoV-2 seroprevalence in high-risk HCWs in a Belgian general hospital after both the first and the second waves. Three different immunoassays were used to determine immune response to SARS-CoV-2 in volunteer HCWs who worked in at least one COVID-19-dedicated ward [emergency department, intensive care unit (ICU) and internal medicine department] in our institution from 8 May 2020 to 19 May 2020 (n = 267) and from 18 January 2021 to 8 February 2021 (n = 189). Risk factors for seropositivity were also assessed using a questionnaire filled out by all participants. We report a steep increase in seroprevalence after the second wave and report a higher seropositivity in HCWs than in the general population. Furthermore, we show that ICU personnel and especially nurses exhibit a proportionally lower SARS-CoV-2 seroprevalence. This study documents the rapid increase in SARS-CoV-2 seroprevalence in highly exposed HCWs in a context of high viral circulation prior to vaccination campaigns. Most importantly, it suggests a lower occupational risk in ICU and illustrates the role of diagnostic labeling and use of personal protective equipment during the COVID-19 pandemic.

比利时某综合医院高危医护人员SARS-CoV-2血清阳性率:从第一波到第二波的演变
卫生保健工作者(HCWs)处于抗击持续的严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)大流行的第一线。为了描述最近或过去的感染,血清学检测的新发展使评估冠状病毒病(COVID-19)中产生的免疫反应成为可能。在这里,我们调查了比利时一家综合医院的高危医护人员在第一波和第二波后的SARS-CoV-2血清阳性率。2020年5月8日至2020年5月19日(n = 267)和2021年1月18日至2021年2月8日(n = 189)在我院至少一个covid -19专用病房(急诊科、重症监护病房(ICU)和内科)工作的志愿医护人员,采用三种不同的免疫测定法测定其对SARS-CoV-2的免疫反应。所有参与者还填写了一份调查问卷,对血清阳性的危险因素进行了评估。我们报告了第二波之后血清阳性率的急剧上升,并且报告了HCWs的血清阳性高于一般人群。此外,我们发现ICU人员,特别是护士的SARS-CoV-2血清阳性率比例较低。本研究记录了在疫苗接种运动之前高病毒传播背景下,高度暴露的卫生保健工作者的SARS-CoV-2血清阳性率迅速上升。最重要的是,这表明ICU的职业风险较低,并说明了在COVID-19大流行期间诊断标签和个人防护装备使用的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Clinica Belgica
Acta Clinica Belgica 医学-医学:内科
CiteScore
2.90
自引率
0.00%
发文量
44
审稿时长
6-12 weeks
期刊介绍: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine primarily publishes papers on clinical medicine, clinical chemistry, pathology and molecular biology, provided they describe results which contribute to our understanding of clinical problems or describe new methods applicable to clinical investigation. Readership includes physicians, pathologists, pharmacists and physicians working in non-academic and academic hospitals, practicing internal medicine and its subspecialties.
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