Average and Standard Deviation of the Error Function for Random Genetic Codes with Standard Stop Codons

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Dino G. Salinas
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引用次数: 2

Abstract

The origin of the genetic code has been attributed in part to an accidental assignment of codons to amino acids. Although several lines of evidence indicate the subsequent expansion and improvement of the genetic code, the hypothesis of Francis Crick concerning a frozen accident occurring at the early stage of genetic code evolution is still widely accepted. Considering Crick’s hypothesis, mathematical descriptions of hypothetical scenarios involving a huge number of possible coexisting random genetic codes could be very important to explain the origin and evolution of a selected genetic code. This work aims to contribute in this regard, that is, it provides a theoretical framework in which statistical parameters of error functions are calculated. Given a genetic code and an amino acid property, the functional code robustness is estimated by means of a known error function. In this work, using analytical calculations, general expressions for the average and standard deviation of the error function distributions of completely random codes with standard stop codons were obtained. As a possible biological application of these results, any set of amino acids and any pure or mixed amino acid properties can be used in the calculations, such that, in case of having to select a set of amino acids to create a genetic code, possible advantages of natural selection of the genetic codes could be discussed.

具有标准终止密码子的随机遗传密码误差函数的平均值和标准差
遗传密码的起源部分归因于氨基酸密码子的偶然分配。虽然有几条证据表明遗传密码随后扩展和改进,但弗朗西斯·克里克关于遗传密码进化早期发生冻结事故的假设仍然被广泛接受。考虑到克里克的假设,对涉及大量可能共存的随机遗传密码的假设场景的数学描述对于解释选定遗传密码的起源和进化可能非常重要。这项工作的目的是在这方面作出贡献,即,它提供了一个理论框架,其中误差函数的统计参数的计算。给定一个遗传密码和一个氨基酸属性,功能码的鲁棒性是通过一个已知的误差函数来估计的。本文通过解析计算,得到了具有标准停止密码子的完全随机码的误差函数分布的平均值和标准差的一般表达式。作为这些结果的可能的生物学应用,任何一组氨基酸和任何纯或混合氨基酸性质都可以用于计算,这样,在必须选择一组氨基酸来创建遗传密码的情况下,可以讨论遗传密码的自然选择的可能优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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