Antimicrobial resistance in neonates with suspected sepsis.

IF 1.3 Q4 RESPIRATORY SYSTEM

Public Health Action Pub Date : 2021-11-01 DOI:10.5588/pha.21.0038

S K Yadav, S K Agrawal, S K Singh, A Giri, G K Singh, R Ghimire, A G Stewart, K L Show, F L Moses

{"title":"Antimicrobial resistance in neonates with suspected sepsis.","authors":"S K Yadav, S K Agrawal, S K Singh, A Giri, G K Singh, R Ghimire, A G Stewart, K L Show, F L Moses","doi":"10.5588/pha.21.0038","DOIUrl":null,"url":null,"abstract":"Setting: Nobel Medical College and Teaching Hospital, Biratnagar, Nepal.Objective: To determine the pattern of antimicrobial resistance and hospital exit outcomes in neonates with suspected sepsis in a tertiary neonatal intensive care unit (NICU).Design: This hospital-based cohort study was conducted to follow patients from January to December 2019. All identified cases of suspected sepsis were enlisted from hospital records.Results: Sepsis was suspected in 177 (88%) of the 200 cases admitted in the NICU; 52 (29%) were culture-positive. Pseudomonas was the predominant organism isolated (n = 40; 78%), followed by coagulase negative staphylococcus (n = 12, 23%). Nine (17%) of the 52 isolates were resistant to the Access and Watch group of antibiotics, including some resistance to Reserve group drugs such as imipenem and linezolid. Most treated cases (n = 170, 96%) improved, although 7 (4%) left against medical advice.Conclusion: Most of the pathogens were resistant to WHO Access and Watch antibiotics and occasional resistance was observed to Reserve group drugs. Most sepsis was caused by Gram-negative bacilli. Improving turnaround times for antibiotic sensitivity testing using point-of-care testing, and a greater yield of culture-positive results are needed to enhance the management of neonatal sepsis.","PeriodicalId":46239,"journal":{"name":"Public Health Action","volume":"11 Suppl 1","pages":"6-12"},"PeriodicalIF":1.3000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575386/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Public Health Action","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5588/pha.21.0038","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}

引用次数: 0

Abstract

Setting: Nobel Medical College and Teaching Hospital, Biratnagar, Nepal.

Objective: To determine the pattern of antimicrobial resistance and hospital exit outcomes in neonates with suspected sepsis in a tertiary neonatal intensive care unit (NICU).

Design: This hospital-based cohort study was conducted to follow patients from January to December 2019. All identified cases of suspected sepsis were enlisted from hospital records.

Results: Sepsis was suspected in 177 (88%) of the 200 cases admitted in the NICU; 52 (29%) were culture-positive. Pseudomonas was the predominant organism isolated (n = 40; 78%), followed by coagulase negative staphylococcus (n = 12, 23%). Nine (17%) of the 52 isolates were resistant to the Access and Watch group of antibiotics, including some resistance to Reserve group drugs such as imipenem and linezolid. Most treated cases (n = 170, 96%) improved, although 7 (4%) left against medical advice.

Conclusion: Most of the pathogens were resistant to WHO Access and Watch antibiotics and occasional resistance was observed to Reserve group drugs. Most sepsis was caused by Gram-negative bacilli. Improving turnaround times for antibiotic sensitivity testing using point-of-care testing, and a greater yield of culture-positive results are needed to enhance the management of neonatal sepsis.

查看原文本刊更多论文

疑似败血症新生儿的抗菌药耐药性。

地点：尼泊尔比拉德讷格尔诺贝尔医学院和教学医院尼泊尔比拉德讷格尔诺贝尔医学院和教学医院：确定三级新生儿重症监护病房（NICU）中疑似败血症新生儿的抗菌药耐药性模式和出院结果：这项基于医院的队列研究对2019年1月至12月的患者进行了追踪。所有疑似败血症病例均来自医院病历：在新生儿重症监护室收治的 200 例病例中，177 例（88%）疑似败血症；52 例（29%）培养阳性。假单胞菌是最主要的分离菌（n = 40；78%），其次是凝固酶阴性葡萄球菌（n = 12，23%）。52 个分离株中有 9 个（17%）对 Access 和 Watch 类抗生素产生耐药性，包括对亚胺培南和利奈唑胺等 Reserve 类药物产生耐药性。大多数接受治疗的病例（n = 170，96%）病情有所好转，但有 7 例（4%）病例不听医嘱离开了医院：结论：大多数病原体对世界卫生组织准入抗生素和观察抗生素具有耐药性，偶尔发现对储备类药物具有耐药性。大多数败血症是由革兰氏阴性杆菌引起的。要加强对新生儿败血症的管理，就需要利用护理点检测改善抗生素敏感性检测的周转时间，并提高培养阳性结果的产量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Public Health Action RESPIRATORY SYSTEM-

自引率

0.00%

发文量

期刊介绍： Launched on 1 May 2011, Public Health Action (PHA) is an official publication of the International Union Against Tuberculosis and Lung Disease (The Union). It is an open access, online journal available world-wide to physicians, health workers, researchers, professors, students and decision-makers, including public health centres, medical, university and pharmaceutical libraries, hospitals, clinics, foundations and institutions. PHA is a peer-reviewed scholarly journal that actively encourages, communicates and reports new knowledge, dialogue and controversy in health systems and services for people in vulnerable and resource-limited communities — all topics that reflect the mission of The Union, Health solutions for the poor.