Adhesins in the virulence of opportunistic fungal pathogens of human.

IF 4.6 2区 生物学 Q1 MYCOLOGY
Mycology Pub Date : 2021-07-05 eCollection Date: 2021-01-01 DOI:10.1080/21501203.2021.1934176
Amrita Kumari, Ankita H Tripathi, Poonam Gautam, Rekha Gahtori, Amit Pande, Yogendra Singh, Taruna Madan, Santosh K Upadhyay
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引用次数: 9

Abstract

Aspergillosis, candidiasis, and cryptococcosis are the most common cause of mycoses-related disease and death among immune-compromised patients. Adhesins are cell-surface exposed proteins or glycoproteins of pathogens that bind to the extracellular matrix (ECM) constituents or mucosal epithelial surfaces of the host cells. The forces of interaction between fungal adhesins and host tissues are accompanied by ligand binding, hydrophobic interactions and protein-protein aggregation. Adherence is the primary and critical step involved in the pathogenesis; however, there is limited information on fungal adhesins compared to that on the bacterial adhesins. Except a few studies based on screening of proteome for adhesin identification, majority are based on characterization of individual adhesins. Recently, based on their characteristic signatures, many putative novel fungal adhesins have been predicted using bioinformatics algorithms. Some of these novel adhesin candidates have been validated by in-vitro studies; though, most of them are yet to be characterised experimentally. Morphotype specific adhesin expression as well as tissue tropism are the crucial determinants for a successful adhesion process. This review presents a comprehensive overview of various studies on fungal adhesins and discusses the targetability of the adhesins and adherence phenomenon, for combating the fungal infection in a preventive or therapeutic mode.

Abstract Image

Abstract Image

Abstract Image

粘附素在人机会真菌致病菌毒力中的作用。
曲霉病、念珠菌病和隐球菌病是免疫功能低下患者中真菌相关疾病和死亡的最常见原因。黏附素是病原体的细胞表面暴露蛋白或糖蛋白,可与宿主细胞的细胞外基质(ECM)成分或粘膜上皮表面结合。真菌黏附素与宿主组织之间的相互作用力伴随着配体结合、疏水相互作用和蛋白质-蛋白质聚集。依从性是发病机制的主要和关键步骤;然而,与细菌黏附素相比,真菌黏附素的研究资料有限。除了少数基于蛋白质组筛选黏附素鉴定的研究外,大多数都是基于单个黏附素的表征。最近,基于它们的特征特征,使用生物信息学算法预测了许多假定的新型真菌粘附素。其中一些新的候选黏附素已被体外研究证实;不过,它们中的大多数还有待实验鉴定。形态特异性粘附素的表达以及组织趋向性是成功粘附过程的关键决定因素。本文综述了真菌粘附素的各种研究,并讨论了粘附素的靶向性和粘附现象,以预防或治疗方式对抗真菌感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Mycology
Mycology Medicine-Infectious Diseases
CiteScore
9.10
自引率
0.00%
发文量
18
审稿时长
13 weeks
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