Hippocampal Subfield Volumes and Cognitive Function in Schizophrenia and Mood Disorders.

IF 2.3 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2022-01-01 Epub Date: 2022-01-14 DOI:10.1159/000521102

Kasumi Yasuda, Shinichi Yamada, Shinya Uenishi, Natsuko Ikeda, Atsushi Tamaki, Yuji Ohoshi, Tomikimi Tsuji, Shun Takahashi

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引用次数: 5

Abstract

Introduction: The hippocampus is relevant to cognitive function in schizophrenia (SCZ) and mood disorder patients. Although not anatomically uniform, it is clearly divided into subfields. This study aimed to elucidate the relationship between hippocampal subfield volume and cognitive function in patients with SCZ, bipolar disorder (BP), and major depressive disorder (MDD).

Methods: The study included 21 patients with SCZ, 22 with BP, and 21 with MDD and 25 healthy controls (HCs). Neurocognitive function was assessed using the Brief Assessment of Cognition in Schizophrenia. We obtained hippocampal subfield volumes using FreeSurfer 6.0. We compared the volumes of the hippocampal subfield between the 4 groups and ascertained correlation between the cognitive composite score and hippocampal subfield volume in each group.

Results: The SCZ group had significantly lower cognitive composite score than the BP, MDD, and HC groups. In the SCZ group, the left and right hippocampus-amygdala transition area and right subiculum and right presubiculum volumes were significantly reduced compared to those in the HC group. The left presubiculum volumes in the SCZ group were significantly reduced compared to those in the MDD group. Subfield volumes did not significantly differ between the BP, MDD, and HC groups. Interestingly, in the SCZ group, volumes of the right CA1, right molecular layer of the hippocampus, and right granule cell and molecular layer of the dentate gyrus were significantly correlated with the cognitive composite score.

Conclusion: Patients with SCZ had poorer cognitive function, which is related to their hippocampal pathology, than those with mood disorders.

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精神分裂症和情绪障碍的海马体亚区体积和认知功能。

简介:海马体与精神分裂症(SCZ)和心境障碍患者的认知功能有关。虽然在解剖学上不一致，但它清楚地分为子场。本研究旨在阐明SCZ、双相情感障碍(BP)和重度抑郁障碍(MDD)患者海马亚区体积与认知功能的关系。方法:研究对象为21例SCZ患者、22例BP患者、21例重度抑郁症患者和25例健康对照(hc)。神经认知功能采用精神分裂症患者认知能力简要评估。我们使用FreeSurfer 6.0获得海马子区体积。比较各组海马子区体积，确定认知综合评分与各组海马子区体积的相关性。结果:SCZ组认知综合评分明显低于BP、MDD、HC组。与HC组相比，SCZ组左、右海马-杏仁核过渡区、右枕下、右枕前体积均显著减小。与MDD组相比，SCZ组左侧骨下前体积显著减少。BP组、MDD组和HC组的子区体积无显著差异。有趣的是，在SCZ组，右侧CA1、海马右侧分子层、齿状回右侧颗粒细胞和分子层的体积与认知综合评分显著相关。结论:SCZ患者认知功能较差，与心境障碍患者的海马病理有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.