Double-responsive hyaluronic acid-based prodrugs for efficient tumour targeting

IF 8.1 1区 工程技术 Q1 MATERIALS SCIENCE, BIOMATERIALS
Vincenzo Quagliariello , Arianna Gennari , Som Akshay Jain , Francesco Rosso , Rosario Vincenzo Iaffaioli , Alfonso Barbarisi , Manlio Barbarisi , Nicola Tirelli
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引用次数: 7

Abstract

Hyaluronic acid (HA)-based prodrugs bearing double-responsive (acid pH or oxidation) boronates of catechol-containing drugs were used to treat xenografted human prostate tumours (LNCaP) in SCID mice. The HA prodrugs accumulated significantly only in tumours (impressively, up to 40% of the injected dose after 24 h) and in liver, with negligible – actually anti-inflammatory - consequences in the latter. A quercetin-HA prodrug significantly slowed down tumour growth, in a dose-dependent fashion and with a much higher efficacy (up to 4 times) than equivalent doses of free quercetin. In short, boronated HA appears to be a very promising platform for targeted chemotherapy.

Abstract Image

基于透明质酸的双反应前药有效靶向肿瘤
以透明质酸(HA)为基础的前药含有儿茶酚类药物的双响应(酸性pH或氧化)硼酸盐,用于治疗SCID小鼠的异种移植人前列腺肿瘤(LNCaP)。透明质酸前药仅在肿瘤(令人印象深刻的是,24小时后高达注射剂量的40%)和肝脏中显著积累,后者的效果可以忽略不计——实际上是抗炎作用。槲皮素- ha前药以剂量依赖的方式显著减缓肿瘤生长,其功效远高于同等剂量的游离槲皮素(高达4倍)。简而言之,硼化透明质酸似乎是一个非常有前途的靶向化疗平台。
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来源期刊
CiteScore
12.60
自引率
0.00%
发文量
28
审稿时长
3.3 months
期刊介绍: Materials Today is a community committed to fostering the creation and sharing of knowledge and experience in materials science. With the support of Elsevier, this community publishes high-impact peer-reviewed journals, organizes academic conferences, and conducts educational webinars, among other initiatives. It serves as a hub for advancing materials science and facilitating collaboration within the scientific community.
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